Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Sample mechanical transport means in or for automated...
Patent
1997-05-09
2000-03-14
Snay, Jeffrey
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Sample mechanical transport means in or for automated...
422 8208, 436 86, 436172, 2504581, G01N 2164
Patent
active
060369205
ABSTRACT:
The present invention provides an assay apparatus for that includes a temperature adjusting device for simultaneously heating a plurality of samples, and a receiving device for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving device can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving device can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting device can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
REFERENCES:
patent: 4580895 (1986-04-01), Patel
patent: 4626684 (1986-12-01), Landa
patent: 4628026 (1986-12-01), Gardell et al.
patent: 4774055 (1988-09-01), Wakatake et al.
patent: 4778763 (1988-10-01), Makiguchi et al.
patent: 5255976 (1993-10-01), Connelly
patent: 5290513 (1994-03-01), Berthold et al.
patent: 5314825 (1994-05-01), Weyrauch et al.
patent: 5324635 (1994-06-01), Kawase et al.
patent: 5340747 (1994-08-01), Eden
patent: 5355215 (1994-10-01), Schroeder et al.
patent: 5383023 (1995-01-01), Walleczek
patent: 5436718 (1995-07-01), Fernandes et al.
patent: 5463564 (1995-10-01), Agrafiotis et al.
patent: 5496519 (1996-03-01), Schacher
patent: 5525300 (1996-06-01), Danssaert et al.
patent: 5557398 (1996-09-01), Wechsler et al.
patent: 5585277 (1996-12-01), Bowie et al.
patent: 5589351 (1996-12-01), Harootunian
patent: 5599504 (1997-02-01), Hosoi et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5679582 (1997-10-01), Bowie et al.
Volkin et al., "Physical Stabilization of Acidic Fibroblast Growth Factor by Polyanions", Archives of Biochemistry and Biophysics, vol. 300, No. 1, pp. 30-41, (Jan. 1993).
Volkin et al., "The Effect of Polyanions on the Stabilization of Acidic Fibroblast Growth Factor", Harnessing Biotechnology for the 21.sup.st Century, ed. Ladisch, M. and A. Bose, pp. 298-302, (1992).
Freire, E., Methods in Enzymology, vol. 259: Energetics of Biological Macromolecules, ed. Johnson, M. L. and G. K. Ackers, pp. 144-168, (1995).
Chavan et al., "Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF-1)", Biochemistry, vol. 33, No. 23, 1994, pp. 7193-7202.
Cytocalc.TM. Data Analysis System User's Guide, PerSeptive Biosystems, Apr. 1995.
CytoFluor.TM. II Fluorescence Multi-Well Plate Reader User's Guide, PerSeptive Biosystems, Aug. 1995.
Higuchi et al., "Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions", Bio/Technology, vol. 11, Sep. 1993, pp. 1026-1030.
Morton et al., "Energetic Origins of Specificity of Ligand Binding in an Interior Nonpolar Cavity of T4 Lysozyme", Biochemistry, vol. 34, No. 27, 1995, pp. 8564-8575.
Phase I Grant Application for Michael Pantoliano for Automated Receptor Screening by Thermal Physical Assays, Department of Health and Human Services Form PHS-6246-1, dated Aug. 11, 1994.
Pilch, Daniel S. and Kenneth J. Breslauer, "Ligand-induced formation of nucleic acid triple helices", Proccedings of the National Academy of Sciences USA, vol. 91, Sep. 1994, pp. 9332-9336.
Ramsay, Glen and Maurice R. Eftinik, "A Multidimensional Spectrophotometer for Monitoring Thermal Unfolding Transitions of Macromolecules", Biophysical Journal, Vo. 31, Feb. 1994. pp. 516-523.
"Temperature Cyclers: RoboCycler.RTM. Gradient Temperature Cyclers", Stratagene Product Catalog 1997-1998, pp. 236-237.
Tsai et al., "Formulation Design of Acidic Fibroblast Growth Factor", Pharmaceutical Research, vol. 10, No. 5, May 1993, pp. 649-659.
Waring, Michael J., "Stabilization of Two-Stranded Ribohomopolymer Helices and Destabilization of a Three-Stranded Helix by Ethidium Bromide", The Biochemical Journal, vol. 143, 1974, pp. 483-486.
Waring, M.J. and S.M. Henley, "Stereochemical aspects of the interaction between steroidal diamines and DNA", Nucleic Acids Research, vol. 2, No. 4, Apr. 1975, pp. 567-585.
Weber et al., "Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin", Journal of the American Chemical Society, vol. 116, No. 7, 1994, pp. 2717-2724.
Phase II Grant Application for Michael Pantoliano for Automated Receptor Screening by Thermal Physical Assays, Department of Health and Human Services Form PHS-6246-2, dated Dec. 14, 1995.
Eftink, "The Use of Fluorescence Methods to Monitor Unfolding Transitions in Proteins," Biophysical J., vol. 66, Feb. 1994, pp. 482-501.
Bone Roger F.
Pantoliano Michael W.
Rhind Alexander W.
Salemme Francis R.
3-Dimensional Pharmaceuticals Inc.
Snay Jeffrey
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