Microparticulate microbubble-generating contrast agents

Details Microparticulate microbubble-generating contrast agents Microparticulate microbubble-generating contrast agents

1995-06-07

1998-10-27

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

424 951, 424 937, A61K 4904, A61B 5055

Patent

active

058275029

ABSTRACT:
The present invention relates to contrast agents comprising microbubble-generating carbohydrate particles having a surfactant admixed within the microparticulate structure, wherein the microbubbles generated by the microparticles comprise a biocompatible low molecular weight fluorinated hydrocarbon. The contrast agents exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.

REFERENCES:
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5393524 (1995-02-01), Quay
patent: 5531980 (1996-07-01), Schneider et al.
patent: 5558856 (1996-09-01), Klaveness et al.

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