Microparticles with adsorbent surfaces, methods of making...

Details Microparticles with adsorbent surfaces, methods of making... Microparticles with adsorbent surfaces, methods of making...

2005-04-26

2005-04-26

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S455000, C424S490000, C514S04400A, C435S320100, C536S023100

Reexamination Certificate

active

06884435

ABSTRACT:
The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for raising an immune response, for treatment of a disease and for diagnosis of a disease. The microparticles comprise a biodegradable polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, and a detergent selected from a cationic detergent and an anionic detergent. The microparticles further comprise an antigen adsorbed on the surface of the microparticle.

REFERENCES:
patent: 4413057 (1983-11-01), Carlo et al.
patent: 4534996 (1985-08-01), Rembaum et al.
patent: 5010183 (1991-04-01), Macfarlane
patent: 5630922 (1997-05-01), Eswarakrishnan et al.
patent: 5643605 (1997-07-01), Cleland et al.
patent: 5714354 (1998-02-01), Arnold et al.
patent: 5783567 (1998-07-01), Hedley et al.
patent: 5830430 (1998-11-01), Unger et al.
patent: 5869103 (1999-02-01), Yeh et al.
patent: 5871747 (1999-02-01), Gengoux-Sedlik et al.
patent: 5902565 (1999-05-01), Cox et al.
patent: 6086901 (2000-07-01), O'Hagan et al.
patent: WO 9415635 (1994-07-01), None
patent: WO 9428879 (1994-12-01), None
patent: WO 9524929 (1995-09-01), None
patent: WO 9620698 (1996-07-01), None
patent: WO 9702810 (1997-01-01), None
patent: WO 9724447 (1997-07-01), None
patent: WO 9810750 (1998-03-01), None
patent: WO 9833487 (1998-08-01), None
Bertling et al., Use of Lipsomes, Viral Capsids, and Nanoparticles as DNA Carriers, Biotechnology and Applied Biochemistry, vol. 13, pp. 390-405 (1991).*
Moore et al. Vaccine, 13/18:1741-1749, 1995.*
Haynes et al. AIDS Research and Human Retroviruses, 10, Suppl. 2:S42-S45, 1994.*
A.G.A. Coombes et al., “Single Dose, Polymeric, Microparticle-based Vaccines: The Influence of Formulation Conditions on the Magnitude and Duration of the Immune Response to a Protein Antigen,”Vaccine, 14(15): 1429-1438 (1996).
Jacqueline D. Duncan et al., “Poly(lactide-co-glycolide) Microencapsulation of Vaccines for Mucosal Immunization,”Mucosal Vaccines(Academic Press, 1996), pp. 159-173.
John H. Eldridge et al., “Biodegradable and Biocompatible Poly(DL-Lactide-Co-Glycolide) Microspheres as an Adjuvant for Staphylococcal Enterotoxin B Toxoid Which Enhances the Level of Toxin-Neutralizing Antibodies,”Infection and Immunity59(9):2978-2986 (1991).
John H. Eldridge et al., “New Advances in Vaccines in Vaccine Delivery Systems,”Seminars in Hematology30(4):16-25 (1993).
Deborah A. Higgins et al., “MF59 Adjuvant Enhances the Immunogenicity of Influenza Vaccine in Both Young and Old Mice,”Vaccine14(6):478-484 (1996).
Ying Men et al., “Induction of a Cytotoxic T Lymphocyte Response by Immunization with a Malaria Specific CTL Peptide Entrapped in Biodegradable Polymer Microspheres,”Vaccine15(12-13):1405-1412 (1997).
Ryusuke Nakaoka et al., “Enhanced Antibody Production Through Sustained Antigen Release from Biodegradable Granules,”Journal of Controlled Release37:215-224 (1995).
D.T. O'Hagan et al., “Long-Term Antibody Responses in Mice Following Subcutaneous Immunization with Ovalbumin Entrapped in Biodegradable Particles,”Vaccine11(9):965-969 (1993).
D.T. O'Hagan et al., “Biodegradable Microparticles for Oral Immunization,”Vaccine11:149-154 (1993).
Michael F. Powell et al., eds.,Vaccine Design: The Subunit and Adjuvant Approach, Plenum Press, New York, p. 183 (1995).
Hongkee Sah et al., “Continuous Release of Proteins from Biodegradable Microcapsules and in Vivo Evaluation of Their Potential as a Vaccine Adjuvant,”Journal of Controlled Release35:137-144 (1995).
H.M. Vordermeier et al., “Synthetic Delivery System for Tuberculosis Vaccines: Immunological Evaluation of theM. tuberculosis38 kDa Protein Entrapped in Biodegradable PLG Microparticles,”Vaccine13(16):1576-1582 (1995).
Chavany, Christine et al., “Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake,” Pharmaceutical Research, vol. 11, No. 9, 1994, pp. 1370-1378.
Fattal, Elias et al., “Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of olionucleotides,” Journal of Controlled Release 53 (1998), pp. 137-143.

Affiliated with

Also associated with

Rating

Microparticles with adsorbent surfaces, methods of making... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microparticles with adsorbent surfaces, methods of making..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microparticles with adsorbent surfaces, methods of making... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3413628