Microparticles for delivery of nucleic acid

Details Microparticles for delivery of nucleic acid Microparticles for delivery of nucleic acid

1997-01-22

1998-07-21

Degen, Nancy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 536231, A61K 4800, C12N 1563, C12N 1511

Patent

active

057835675

ABSTRACT:
Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled.

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