Microparticles as ultrasonic contrast media

Surgery – Truss – Pad

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12866001, A61B 800

Patent

active

053336135

ABSTRACT:
Ultrasonic contrast media are provided comprising small particles with entrapped gas, where the compositions can be selected for rapid dissolution with production of microbubbles or maintaining the gas in microtubules, microchambers or microcracks, providing for echogenicity. The particles are readily formed by precipitation from a liquid, either solution or melt, of a monomeric material, followed by drying and mechanically reducing the size of the particles.

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patent: 4718433 (1988-01-01), Feinstein
patent: 5088499 (1992-02-01), Unger
Bommer et al., "Indicator-dilution curves obtained by photometric analysis of two-dimension echo-contrast studies", American Journal of Cardiology, 41:370 (1978) (Abstract).
Feigenbaum et al., "Identification of ultrasound echoes from the left ventricle by use of intracardiac injections of indocyanine green", Circulation, 41:615-621 (1970).
Gramiak et al., "Ultrasound cardiography: Contrast studies in anatomy and function", Radiology, 92:939-948 (1969).
Meltzer et al., "The source of ultrasound contrast effect", J. Clin. Ultrasound, 8:121-127 (1980).

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