Microparticle with cd28-specific monoclonal antibodies

Details Microparticle with cd28-specific monoclonal antibodies Microparticle with cd28-specific monoclonal antibodies

2011-01-11

2011-01-11

Ouspenski, Ilia (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

Reexamination Certificate

active

07868143

ABSTRACT:
The invention relates to microparticles with a support structure and CD28-specific superagonistic monoclonal antibodies (mAbs) bonded to the support structure or a compound mimicking the above.

REFERENCES:
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patent: 100 50 935 (2002-05-01), None
patent: WO 98/54225 (1998-12-01), None
Huang Z., Pharmacology and Therapeutics, 2000, 86: 201-215.
Bonhyadi, M. et al., “Xcellerate: An Autologous T Cell Immunotherapy Approach for Treating B-Cell Lymphocyticleukemia (B-CLL),”Blood, Nov. 16, 2000, Abstract only, 1 page.
Broeren, Chris P. et al., “Costimulation Light: Activation of CD4+ T Cells with CD80 or CD86 Rather Than Anti-DC28 Leads to a TH2 Cytokine Profile,”The Journal of Immunology, 2000, 165: 6908-6914.
Mengozzi, Manuela et al., “Naïve CD4 cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells,”PNAS, Sep. 25, 2001, vol. 98, No. 20, pp. 11644-11649.
Dynabeads® M-450 Tosylactivated, Dynal® Biotech, pp. 1-8, date unknown, but prior to the filing date of the instant application, (Jul. 4, 2002).
“Are you new to the Dynabeads® Technology?,” http://www.dynal.no/kunder/dynal/dynalpub401.nsf/print/9F9F14DDD7BF78E6C125..., downloaded Jul. 21, 2003, 2 pages.

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