Microparticle preparation and production thereof

Details Microparticle preparation and production thereof Microparticle preparation and production thereof

1996-03-07

1998-03-03

Venkat, Jyothsan

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 264432, 264 46, 42840221, 514963, A61K 958

Patent

active

057232695

ABSTRACT:
A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are at least partially or wholly coated with a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid, which acts as an agent for preventing aggregation of the microparticle preparation is disclosed. The preparation is produced by spraying a polymer solution containing a drug and a solution or dispersion of a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid from different nozzles and contacting them with each other in a spray dryer. In this procedure, if desired, a non-ionic surfactant may be added to the solution of the water-soluble inorganic salt, the water-soluble organic acid or the water-soluble salt of organic acid, or a solution of non-ionic surfactant may be sprayed from the other nozzle simultaneously.

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patent: 5061492 (1991-10-01), Okada et al.
patent: 5271945 (1993-12-01), Yoshioka et al.
Remingtons Pharmaceutical Suemes pp. 1630-1631 (1985).
Journal of Pharmacy and Pharmacology, 1988, vol. 40, pp. 754-757.

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