Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1994-05-18
1996-11-05
Housel, James C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424408, 424488, 424499, 4241841, 4242091, 4242311, A61K 956, A61K 950, A61K 914, A01N 2534
Patent
active
055715311
ABSTRACT:
A particulate carrier for an agent comprising a solid core of a polysaccharide and a proteinaceous material and an organometallic polymer bonded to the core is provided. The agent has a biological activity, such as immunogenicity, and may comprise the proteinaceous material or be a separate component of the core. Polysaccharide cores include dextran, starch, cellulose and derivatives thereof and the organometallic polymer includes silicones including substituted silicones. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral administration to produce immune responses, including antibody responses.
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Saito, N. et al Yakuzaigaku (1991) 51(2), pp. 73-79 Abstract Only O/W Emulsion of Dimethyl Poly Siloxane for Oral Use Prepared w/Nonionic Surfactants.
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Eldridge, J. H. et al. (1991) Adv. Exp. Med. Biol. pp. 340-345 Vaccine-Containing Biodegrable Microspheres Spec. Enter the Gut. Assoc. Lymphoid Tissue Following Oral Admin. & Induce . . . .
Morris W. et al Vaccine (1994) pp. 5-10 Potential of Polymer Microencapsulation.
Brook Michael A.
Heritage Philippa L.
Jiang Jianxiong
Loomes Lesley M.
McDermott Mark R.
Housel James C.
McMaster University
Shaver Jennifer
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