Microparticle compositions containing peptides, and methods for

Details Microparticle compositions containing peptides, and methods for Microparticle compositions containing peptides, and methods for

1993-12-16

1997-06-03

Mullis, Jeffrey C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514 2, 514 12, A61K 914

Patent

active

056352166

ABSTRACT:
A composition of polyester microparticles containing bioactive polypeptide agents and methods for preparing the composition and administering bioactive agents. The composition comprises biocompatible, biodegradable microparticles having a polyester matrix and from about 5% to about 25% by weight of a biologically active, water-soluble polypeptide dispersed throughout the matrix, the polypeptide selected from the group consisting of growth hormone releasing factor, synthetic analogs of growth hormone releasing factor, pharmacologically active fragment thereof and somatogenin. The method for preparing the composition includes dissolving polyester in an organic solvent; suspending a biologically active agent in the polyester solution; emulsifying the suspension into an aqueous medium in which the agent is insoluble and evaporating the solvent from the emulsion to produce microparticles. The method for administering a bioactive agent to an organism involves suspending the microparticles in a suitable liquid and injecting the organism.

REFERENCES:
patent: 4148871 (1979-04-01), Pitt et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4542025 (1985-09-01), Tice et al.
patent: 4741872 (1988-05-01), De Luca et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 5192741 (1993-03-01), Orsolini et al.
patent: B14767628 (1990-07-01), Hutchinson
P. Couvreur and F. Puisieux, "Nano- and microparticles for the delivery of polypeptides and proteins", Advanced Drug Delivery Reviews, 1993, vol. 10, pp. 141-162 May-Jun.
Reza Arshady, "Microspheres and Microcapsules, a Survey of Manufacturing Techniques: Part III: Solvent Evaporation", Polymer Engineering and Science, Mid-Aug., 1990, vol. 30, No. 15, pp. 915-924.
H.. Jeffrey, et al., "The preparation and characterisation of poly(lactide-co-glycolide) microparticles. I: Oil-in-water emulsion solvent evaporation", International Journal of Pharmaceutics, 1991, vol. 77, pp. 169-175 Oct.
Hua-Pin Huang and Isaac Ghebre-Sellassie, "Preparation of microspheres of water-soluble pharmaceuticals", J. Microencapsulation, 1989, vol. 6, No. 2, pp. 219-225 Apr.-Jun.
D. Bodmer, et al., "Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems", Journal of Controlled Release, 1992, vol. 21, pp. 129-138 Jul.
B. Mariette, et al., "Release of the GRF29NH.sub.2 analog of human GRF44NH.sub.2 from a PLA/GA matrix", Journal of Controlled Release, 1993, vol. 24, pp. 237-246 Jun.
B. Floy, et al., "Design of Biodegradable Polymer Systems for Controlled Release of Bioactive Agents", Polymeric Delivery Systems, American Chemical Society, 1993, pp. 154-167 (month unavailable).
V.J. Csernus, et al., "Release of peptides from sustained delivery systems (microcapsules and microparticles) in vivo", Int. J. Peptide Protein Res., 1990, vol. 35, pp. 557-565 Jun.
R. Jalil and J.R. Nixon, "Microencapsulation using poly(DL-lactic acid)I: Effect of preparative variables on the microcapsules characteristics and release kinetics", J Microencapsulation, 1990, vol. 7, No. 2, pp. 229-244 Apr.-Jun.
J.L. Grangier, et al., "Nanoparticles as carriers for growth hormone releasing factor", Journal of Controlled Release, 1991, vol. 15, pp. 3-13 Feb.

Affiliated with

Also associated with

Rating

Microparticle compositions containing peptides, and methods for does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microparticle compositions containing peptides, and methods for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microparticle compositions containing peptides, and methods for will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-389624