Microparticle complexes with 2-amino-1-phenylpropanol materials

Details Microparticle complexes with 2-amino-1-phenylpropanol materials Microparticle complexes with 2-amino-1-phenylpropanol materials

1997-05-21

1998-11-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

414434, 414485, 414401, 514649, A61K 914

Patent

active

058305092

ABSTRACT:
Microparticulate carrier materials for a large and varied group of pharmaceutical and cosmetic agents are disclosed. Microdispersions of such carrier materials charged with at least one isomer or derivative of 2-amino-1-phenylpropanol are also described. The microdispersions can be formulated for oral, parenteral, topical, inhalation and suppository administration. The formulations have varied uses depending on the pharmaceutical and or cosmetic agent utilized. The microparticles are suitably charged particles of silica, alumina, boron, charcoal and the like and have a particle size of about 3 to about 250 .mu.m. The pharmaceutical and cosmetic active materials complex with the microparticles. The liquid carrier for the microparticles include water, propylene glycol, alcohols such as methanol, ethanol and propanols, and dimethyl sulfoxide. The resulting dispersions are believed to be similar to isotonic saline and mimic body fluids which makes the dispersions very physiologically compatible thereby aiding and speeding the delivery of the agents across membranes and to the afflicted tissue. Methods of using these microdispersions and the containing the same are also disclosed.

REFERENCES:
patent: 5521220 (1996-05-01), O'Neill

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