Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2005-03-01
2009-10-20
Kosson, Rosanne (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C435S069100, C435S193000, C435S232000, C514S733000, C514S734000, C514S738000, C568S729000
Reexamination Certificate
active
07604968
ABSTRACT:
The invention provides methods and materials related to producing flavonoids as well as other organic compounds. For example, the invention provides isolated nucleic acids, polypeptides, host cells, and methods and materials for producing flavonoids and other organic compounds.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5349125 (1994-09-01), Holton et al.
patent: 5569832 (1996-10-01), Holton et al.
patent: 5639870 (1997-06-01), Holton et al.
patent: 5859334 (1999-01-01), Brugliera et al.
patent: 5861487 (1999-01-01), Holton et al.
patent: 5948955 (1999-09-01), Holton et al.
patent: 6005167 (1999-12-01), Van Tunen et al.
patent: 6270780 (2001-08-01), Carson et al.
patent: 2002/0051998 (2002-05-01), Schmidt-Dannert et al.
patent: WO 06/10117 (2006-01-01), None
patent: WO 06/89898 (2006-08-01), None
Becker et al., “Metabolic engineering ofSaccharomyces cerevisiaefor the synthesis of the wine-related antioxidant resveratrol,” FEMS Yeast Research 4:79-85, 2003.
James et al., “Expression of twoEscherichia coliacetyl-coA carboxylase subunits is autoregulated,” J Biol Chem 279(4):2520-2527, 2003.
International Union of Biochemistry and Molecular Biology Enzyme Nomenclature, on-line database, record for phenylalanine ammonia lyase/tyrosine ammonia lyase, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC4/3/1/5.html, printed on Oct. 16, 2007.
Faulkner et al., “High-level expression of the phenylalanine ammonia lyase-encoding gene from Rhodosporidium toruloides inSaccharomyces cerevisiaeandEscherichia coliusing a bifunctional expression system,” Gene 143(1):13-20, 1994.
Chao and Liao, “Alteration of Growth Yield by Overexpression of Phosphoenolpyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase inEscherichia coli,” Appl. Environ. Microbiol., 1993, 59(12):4261-4265.
Austin and Noel, “The chalcone synthase superfamily of type III polykedite synthases,”Nat. Prod. Rep., 2003, 20:79-110.
Becker and Guarente, “High-Efficiency Transformation of Yeast by Electroporation,”Meth. Enzymol., 1991, 194:182-187.
Burritt et al., “Filamentous Phage Display of Oligopeptide Libraries,”Anal. Biochem., 1996, 238:1-13.
Chen et al., “Separation and determination of flavonoids and other phenolic compounds in cranberry juice by high-performance liquid chromatography,”J. Chromatography A., 2001, 913:387-395.
Cusanovich and Meyer, “Photoactive Yellow Protein: A Prototypic PAS Domain Sensory Protein and Development of a Common Signaling Mechanism,”Biochemistry, 2003, 42(17):4759-4770.
Durrens et al., “Expression of the aviangag-myconcogene inSaccharomyces cerevisiae,” Curr. Genet., 1990, 18;7-12.
Guzman et al., “Tight Regulation, Modulation, and High-Level Expression by Vectors Containing the Arabinose PBADPromoter,”J. Bacteriol., 1995, 177(14):4121-4130.
GenBank Accession No. AAB81682 dated Oct. 26, 2000, 2 pages.
GenBank Accession No. AAL16143 dated Oct. 18, 2001, 2 pages.
GenBank Accession No. AAM13084 dated Apr. 21, 2002, 2 pages.
GenBank Accession No. AAM91686 dated Sep. 18, 2002, 2 pages.
GenBank Accession No. AB013596 dated Jun. 6, 2005, 2 pages.
GenBank Accession No. AB027606 dated Dec. 21, 1999, 2 pages.
GenBank Accession No. AF112086 dated Oct. 16, 2000, 2 pages.
GenBank Accession No. AF277052 dated Jul. 18, 2000, 2 pages.
GenBank Accession No. AH009204 dated Dec. 3, 2001,4 pages.
GenBank Accession No. AY167424 dated Jan. 7, 2003, 2 pages.
GenBank Accession No. AY303128 dated Jul. 13, 2005, 3 pages.
GenBank Accession No. BAA19659 dated Feb. 24, 1998, 2 pages.
GenBank Accession No. BAA31259 dated Apr. 14, 2000, 2 pages.
GenBank Accession No. L02902 dated Sep. 24, 1993, 2 pages.
GenBank Accession No. L02904 dated Sep. 24, 1993, 2 pages.
GenBank Accession No. L02905 dated Sep. 24, 1993, 2 pages.
GenBank Accession No. M86358 dated Apr. 2, 1999, 2 pages.
GenBank Accession No. NM—119167 dated Jun. 9, 2006, 3 pages.
GenBank Accession No. NM—123645 dated Jun. 9, 2006, 2 pages.
GenBank Accession No. NP—195634 dated Jun. 9, 2006, 2 pages.
GenBank Accession No. NP—565107 dated Jun. 9, 2006, 2 pages.
GenBank Accession No. Q96323 dated May 16, 2006, 10 pages.
GenBank Accession No. Q96330 dated May 16, 2006, 3 pages.
GenBank Accession No. T51560 dated Feb. 6, 1995, 2 pages.
GenBank Accession No. U18675 dated Mar. 3, 2000, 2 pages.
GenBank Accession No. U33932 dated Mar. 1, 1996, 2 pages.
GenBank Accession No. U71080 dated May 31, 1997, 3 pages.
GenBank Accession No. X66017 dated Apr. 18, 2005, 3 pages.
GenBank Accession no. X80007 dated Apr. 18, 2005, 4 pages.
GenBank Accession No. X82366 dated Apr. 18, 2005, 2 pages.
Hughes et al., “A tandem mass spectrometric study of selected characteristic flavonoids,”Int. J. Mass Spectrom., 2001, 210/211:371-385.
Hull and Celenza, “Bacterial Expression and Purification of the Arabidopsis NADPH-Cytochrome P450 Reductase ATR2,”Prot. Expr. Purif., 2000, 18:310-315.
Hwang et al., “Production of Plant-Specific Flavanones byEscherichia coliContaining an Artificial Gene Cluster,”Appl. Environ. Microbiol., 2003, 69(5):2699-2706.
Ito et al., “Transformation of Intact Yeast Cells Treated with Alkali Cations,”J. Bacteriol., 1983, 153:163-168.
Justesen et al., “Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection,”J. Chromatography A., 1998, 799:101-110.
Kaneko et al., “Heterologous production of flavanones inEscherichia coli: potential for combinatorial biosynthesis of flavonoids in bacteria,”J. Ind. Microbiol. Biotechnol., 2003, 30(8):456-461.
Khlebnikov et al., “Homogeneous expression of the PBADpromoter inEscherichia coliby constitutive expression of the low-affinity high-capacity AraE transporter,”Microbiology, 2001, 147:3241-3247.
Kyndt et al., “Characterization of a bacterial tyrosine ammonia lyase, a biosynthetic enzyme for the photoactive yellow protein,”FEBS Lett., 2002, 512:240-244.
Lee et al., “Biosynthesis of Structurally Novel Carotenoids inEscherichia coli,” Chem. Biol., 2003, 10:453-462.
Mol et al., “Spontaneous and Enzymic Rearrangement of Naringenin Chalcone to Flavanone,”Phytochemistry, 1985, 24(10):2267-2269.
Paiva, “An Introduction to the Biosynthesis of Chemicals Used in Plant-Microbe Communication,” J. Plant Growth Regul., 2000, 19:131-143.
Schmidt-Dannert et al., “Molecular breeding of carotenoid biosynthetic pathways,”Nat. Biotechnol., 2000, 18:750-753.
Weisshaar and Jenkins, “Phenylpropanoid biosynthesis and its regulation,”Curr. Opin. Plant Biol., 1998, 1:251-257.
Winkel-Shirley, “Flavonoid Biosynthesis. A Colorful Model for Genetics, Biochemistry, Cell Biology, and Biotechnology,”Plant Physiol., 2001, 126:485-493.
Yanisch-Perron et al., “Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors,”Gene, 1985, 33:103-119.
Beritognolo et al., “Expression of genes encoding chalcone synthase, flavanone 3-hydroxylase and dihydroflavonol 4-reductase correlates with flavanol accumulation during heartwood formation in Juglans nigra,”Tree Physiology, 2002, 22:291-300.
ExPASy (Expected Protein Analysis System) EC Enzyme: 4.3.1-4.3.25, 1 page, 2008.
Lee et al., “Two Divergent Members of a Tobacco 4-Coumarate:Coenzyme A Ligase (4CL) Gene Family,”Plant Physiol. (1996) 112:193-205.
Watts et al., “Discovery of A Substrate Selectivity Switch in Tyrosine Ammonia-Lyase, a Member of the Aromatic Amino Acid Lyase Family,”Chem&Biol. 13, 1317-1326, Dec. 2006.
Dok-Go et al., “Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten,”
Schmidt-Dannert Claudia
Watts Kevin
Fish & Richardson P.C.
Kosson Rosanne
Regents of the University of Minnesota
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