Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Reexamination Certificate
2007-07-17
2007-07-17
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
C435S183000, C435S189000, C435S193000, C435S232000, C435S252300
Reexamination Certificate
active
10466641
ABSTRACT:
The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
REFERENCES:
patent: 6184006 (2001-02-01), Rieping et al.
patent: 6184007 (2001-02-01), Dusch et al.
patent: 6787334 (2004-09-01), Elischweski et al.
Sigma product Nos. are P2250, P3161 & P9153.
Hermann Theron
Patterson Thomas A.
Pero Janice G.
Yocum R. Roger
BASF - Aktiengesellschaft
Hanley, Esq. Elizabeth A.
Lahive & Cockfield LLP
Milasincic Esq. Debra J.
Saidha Tekchand
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