Microorganism, lactamase enzyme obtained therefrom, and their us

Details Microorganism, lactamase enzyme obtained therefrom, and their us Microorganism, lactamase enzyme obtained therefrom, and their us

1997-09-03

2000-07-18

Prats, Francisco

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435 43, 435 87, 435121, 435106, C12P 4100, C12P 3700, C12P 1938, C12P 1710

Patent

active

060906162

ABSTRACT:
A lactamase enzyme having good stability, capable of hydrolysing an enatiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isolated and cloned, and its structure identified.

REFERENCES:
Taylor, S.J.C., R. McCague, R. Wisdom, C. Lee, K. Dickson, G. Ruecroft, F. O'Brien, J. Littlechild, J. Bevan, S. Roberts and C. Evans (1993) "Development of the Biocatalytic Resolution of 2-azabicyclo[2.2.1]0 hept-5-en-3-one as an entry to Single-Enantiomer Carbocyclic Nucleosides" Tetrahedron Asymmetry,vol. 4, No. 6, pp. 1117-1128.
Brabban, A.D., J. Littlechild and R. Wisdom (1996) "Stereospecific .gamma.-lactamase activity in a Pseudomonas fluorescens species" Journal of Industrial Microbiology,vol. 16, No. 1, pp. 8-14.
Krieg, N.R. (1984) "Bergey's manual of systematic bacteriology" See p. 78, right-hand column, and pp. 179-180.

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