Microorganism for producing C-31 desmethyl FR-900520 cyclic hemi

Details Microorganism for producing C-31 desmethyl FR-900520 cyclic hemi Microorganism for producing C-31 desmethyl FR-900520 cyclic hemi

1991-08-28

1993-03-30

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435899, C12N 100

Patent

active

051983583

ABSTRACT:
Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylated derivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.

REFERENCES:
patent: 3244592 (1966-04-01), Arai
patent: 4242453 (1980-12-01), Umezawa et al.
Arai, et al., Ascomycin, An Antifungal Antibiotic, Journal of Antibiotics, 15, pp. 231-232 (1962).

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