Microorganism and its use for the preparation of glutathione

Details Microorganism and its use for the preparation of glutathione Microorganism and its use for the preparation of glutathione

1984-11-13

1986-06-24

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435175, 435253, 4351721, 435849, C12P 2102, C12N 1118, C12N 120, C12N 1500

Patent

active

045967750

ABSTRACT:
The present invention relates to a new mutant strain induced from a wild strain of the genus Escherichia, which is active upon a .gamma.-glutamyl-L-cystein synthesizing enzyme system and capable of releasing .gamma.-glutamyl-L-cystein synthetase from inhibition by glutathione.
It preferably is Escherichia coli RC 912 (FERM-BP No. 47). The present invention also contemplates the preparation of glutathione by (1) culturing the foregoing strain in a culture medium' or (2) culturing said strain to first accumulate a .gamma.-glutamyl-L-cystein synthesizing enzyme system, and placing the latter into contact with a substrate of L-glutamic acid, L-cysteine and glycerine to form gluthatione by enzymatic reaction.

REFERENCES:
Murata et al., J. Gen. Microbiol., 120(2): 545-547 (1980).
Murata et al., Chemical Abstracts, 92: 159663q, p. 233 (1980).

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