Micronized vitamin C formulation

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

Reexamination Certificate

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Details

C424S489000

Reexamination Certificate

active

07101563

ABSTRACT:
Stable vitamin C (L-ascorbic acid) compositions for topical application, comprising micronized L-ascorbic acid in a substantially non-aqueous carrier having a pH greater than that of skin, and preferably not lower than approximately 5.5 and not greater than approximately 7.5, are described. The composition may further comprise papain as an enzymatic exfoliant in addition to humectants, emollients, viscosity-increasing agents, surfactants, and preservatives. Methods of preparing the micronized L-ascorbic acid for use in the described formulations, by a “wet” micronization process, are also described. The compositions are useful as UV protectants, promoters of collagen synthesis and in the removal and/or treatment of wrinkles.

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Australian Importers, Ltd. invoice dated Jul. 29, 1998.
Confidentiality, Non-Disclosure and Non-Use Agreement dated Jun. 17, 1998.
Letter dated Apr. 23, 1999 from Ronald G. Wheeland, M.D., to Mr. Scott Shapiro.
Letter dated Mar. 1, 1999 from Ronald G. Wheeland, M.D., to Mr. Scott Shapiro.
Letter dated Apr. 22, 1999 from Mark G. Rubin, M.D., to Mr. Scott Shapiro.
Supplemental European Search Report (Mailing Date Mar. 14, 2003).

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