Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-06-13
1983-11-08
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
26039745, A61K 3156, C07J 700
Patent
active
044142099
ABSTRACT:
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after removal of some or all of the propellant from the crystals, is reduced to a particle size permitting inhalation into the human bronchial system when dispersed as an aerosol, the micronized crystalline solvate not thereafter exhibiting crystal growth in the aerosol propellant. The solvate is a new composition of matter which has been characterized by I.R. spectra and the aerosol formulation prepared therefrom has valuable therapeutic properties, particularly in the treatment of asthma.
REFERENCES:
patent: 3312590 (1967-04-01), Elks et al.
patent: 3721687 (1973-03-01), Elks et al.
Brown et al, "British Medical Journal" of Mar. 4, 1972, pp. 585-589.
Mesley, "Chemistry and Industry", dated Sep. 11, 1965, pp. 1594-1595.
Cook Peter B.
Hunt John H.
Allen & Hanburys Limited
Jiles Henry R.
Whittenbaugh Robert C.
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