Micromechanical calorimetric sensor

Details Micromechanical calorimetric sensor Micromechanical calorimetric sensor

1998-03-16

2000-08-01

Ludlow, Jan

Chemistry: analytical and immunological testing

Measurement includes temperature change of the material...

422 51, 422 8212, 436 34, G01N 2520

Patent

active

060965592

ABSTRACT:
A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.

REFERENCES:
patent: 4591550 (1986-05-01), Hafeman et al.
patent: 4963815 (1990-10-01), Hafeman
patent: 5440920 (1995-08-01), Jung et al.
patent: 5445008 (1995-08-01), Wachter et al.
patent: 5719324 (1998-02-01), Thundat et al.
patent: 5739425 (1998-04-01), Binnig et al.
patent: 5807758 (1998-09-01), Lee et al.
patent: 5831181 (1998-11-01), Majumdar et al.
Berger et al., Sens. Their Appl. VIII, Proc. Conf 8th (1997), 71-76, edited by Augousti et al., published by Instittue of Physics Publishing, Bristol, 1997.
Gimzewski et al., Chem. Phys. Lett. (1994), vol. 217, Nos. 5-6, pp. 589-594, 1994.
Chemical Abstracts (Columbus, Ohio) Abstract No. 128:63264: Berger et al., Sens. Their Appl. VIII, Proc. Conf., 8th (1997), 71-76, edited by Augousti et al., published by Institute of Physics Publishing, Bristol, UK, 1997.

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