Chemistry: molecular biology and microbiology – Apparatus – Mutation or genetic engineering apparatus
Patent
1997-07-22
1999-03-02
Redding, David A.
Chemistry: molecular biology and microbiology
Apparatus
Mutation or genetic engineering apparatus
4352852, 4352862, 7386423, 7386425, 935 53, 935 85, C12M 304
Patent
active
058770089
ABSTRACT:
An electromechanical device for driving the tip of a microinjection cannula, or needle, through the outer barrier of a blastocyst, cell, or cell nucleus for the injection of cells or other bioactive materials. Either a flexible frame or a ram moving within a base member is employed. Cannula motion is achieved by means of a piezoelectric stack and spring return system. The thrust motion over a predetermined microscopic distance is achieved without cannula setback prior to the thrust movement. Instead of specially prepared beveled and tipped needles, standard unimproved cannulas or needles can be used.
REFERENCES:
patent: 5114854 (1992-05-01), Bertholdt
C. L. Stewart, "Production of Chimeras between Embryonic Stem Cells and Embroys," in Methods of Enzymology, vol. 225, Academic Press, San Diego, (Title. of vol. 225 Guide to Techniques in Mouse Development by P. M. WAssarman and M. L. DePamphilis). 1993, pp. 823-855.
Hawk James A.
Patek David R.
Remenyik Carl J.
Turner John C.
Woychik Richard P.
Lockheed Martin Energy Research Corporation
Redding David A.
Spicer James M.
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