Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-06-06
2006-06-06
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S058000, C514S059000, C514S04400A, C424S486000, C424S488000, C424S184100, C435S069100, C435S006120, C530S350000, C536S023100, C536S023400
Reexamination Certificate
active
07056901
ABSTRACT:
Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.
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Frechet Jean M. J.
Murthy Niren
Chew Michelle S.
Khare Devesh
Lawrence Berkeley National Laboratory
The Regents of the University of California
Wilson James O.
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