Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1990-04-12
1992-01-07
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424487, 424 7831, 523105, 523409, 523412, 523522, 524522, 526320, A61K 3174
Patent
active
050789945
ABSTRACT:
A copolymer microparticle is presented which is derived from at least about 5 weight percent of free carboxylic acid group-containing vinyl monomers, monomers which have a poly(alkylene oxide) appended thereto, oleophilic monomers and other nonionic hydrophilic monomers. Microgels containing these copolymers having a median water swollen diameter of about 0.01 to about 1.0 micrometer are disclosed. Pharmaceutical and diagnostic compositions are disclosed comprising a therapeutic or diagnostic agent and microgels comprising a copolymer derived from at least about 5 weight percent of non-esterified carboxylic acid group-containing vinyl monomers, oleophilic monomers and other nonionic hydrophilic monomers, with the proviso that when the median water swollen diameter of the microgels is 0.1 micrometer or greater, at least 5 weight percent of the monomers have a poly(alkylene oxide) appended thereto. Diagnostic and therapeutic methods are also disclosed wherein the microgels are substantially protein non-adsorbent and substantially refractory to phagocytosis.
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Nair Mridula
Tan Julia S.
Eastman Kodak Company
Harrison Robert H.
Hawley J. Jeffrey
Page Thurman K.
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