Microfluidic platform of arrayed switchable spin-valve...

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic

Reexamination Certificate

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C435S287200, C435S287300, C435S288300, C435S288500, C422S068100, C422S105000, C422S105000, C360S324000, C360S324100, C360S324110, C360S324110

Reexamination Certificate

active

07981696

ABSTRACT:
Arrays of spin-valve elements that can be selectively activated to trap, hold, manipulate and release magnetically tagged biological and chemical particles, including molecules and polymers. The spin-valve elements that can be selectively activated and deactivated by applying a momentary applied magnetic field thereto. The spin valve element array can be used for selectively sorting and transporting magnetic particles one particle at a time within the array. As the magnetically tagged particles are held by the spin-valve elements, application of an auxiliary magnetic field can be used to apply tension or torsion to the held particles or to move, e.g. rotate, the trapped particles. The arrays of spin-valve elements can be used in a variety of applications including drug screening, nucleic acid sequencing, structural control and analysis of RNA/DNA and protiens, medical diagnosis, and magnetic particle susceptibility and size homogenization for other medical applications.

REFERENCES:
patent: 4843316 (1989-06-01), Hesterman
patent: 5434826 (1995-07-01), Ravipati et al.
patent: 5478527 (1995-12-01), Gustafson et al.
patent: 5793279 (1998-08-01), Nepela
patent: 6175476 (2001-01-01), Huai et al.
patent: 6676813 (2004-01-01), Pelekhov et al.
patent: 6775110 (2004-08-01), Hayashi et al.
patent: 2002/0024778 (2002-02-01), Xue et al.
patent: 2002/0081714 (2002-06-01), Jain et al.
patent: 2002/0086443 (2002-07-01), Bamdad
patent: 2005/0100930 (2005-05-01), Wang et al.
patent: 2006/0020371 (2006-01-01), Ham et al.
Ferreira et al., “Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited)”, Journal of Applied Physics, May 15, 2003, vol. 93, pp. 7281-7286.
Freitas et al., “Magnetoresistive biochips”, Euorphysics News, 2003, vol. 34, No. 6, pp. 1-8.
Gao et al., “A study of magnetic interactions of Ni80Fe20 arrays using ultrasensitive microcantilever torque magnetometry”, Journal of Applied Physics, Jun. 1, 2004, vol. 95, pp. 7010-70127.
Graham et al., “Magnetoresistive-based biosensors and biochips”, Trends in Biotechnology, Sep. 2004, vol. 11, pp. 455-462 (available online Jul. 2, 2004).
Grutter et al., “Batch fabricated sensors for magnetic force microscopy”, Applied Physics Letters, Oct. 22, 1990, vol. 57, pp. 1820-1822.
Joshi et al., “Biochemical stability of components for use in a DNA detection system”, IEEE Transactions on Magnetics, Jul. 4, 2004, vol. 40, pp. 3012-3014.
Li et al., “Detectin of a single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications”, Journal of Applied Physics, May 15, 2003, vol. 93, pp. 7557-7559.
Li et al., “Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications”, Sensors and Actuators A, 2006, vol. 126, pp. 98-106.
Mirowski et al., “Lateral manipulation of magnetic particles in a microfluidic platform of arrayed magnetic elements: the road to high throughput sorting and probing of biological molecules”, Annual APS March Meeting 2004, Mar. 22-26, 2004, Montreal, Quebec, Canada.
Mirowski et al., “Integrated microfluidic isolation platform for magnetic particle manipulation in biological systems”, Applied Physics Letters, Mar. 8, 2004, Vo. 84, pp. 1786-1788.
Mirowski et al., “Manipulation and sorting of magnetic particles by a magnetic force microscope on a microfluidic magnetic trap platform”, Applied Physics Letters, 2005, vol. 86, pp. 243901-1-243901-3.
Moreland, “Nanoprobe imaging”, Electronics and Electrical Engineering Laboratory, Magnetic Technology Division Programs, Activities, and Accomplishments, Jan. 2003, pp. 14-20.
Moreland, “Micromechanical instruments for ferromagnetic measurements”, Journal of Physics D: Applied Physics, 2003, vol. 36, pp. R39-R51.
Ramachandran et al., “Direct and controlled manipulation of nanometer-sized particles using non-contact atomic force microscope”, Nanotechnology, 1998, vol. 9, pp. 237-245.
Choi et al., “Development and characterization of a generic microfluidic subsystem toward portable biochemical detection”, Micro Total Analysis Systems, 2000, pp. 327-330.
Choi et al., “An integrated microfluidic biochemical detection system with magnetic bead-based sampling and analysis capabilities”, Micro Electro Mechanical Systems, The 14th IEEE International Conference, Jan. 2001, pp. 447-450.
Graham et al., “Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications”, Journal of Applied Physics, May 15, 2002, vol. 91, pp. 7786-7788.

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