Chemistry: analytical and immunological testing – Biological cellular material tested
Reexamination Certificate
2003-12-11
2008-11-18
Sines, Brian J (Department: 1797)
Chemistry: analytical and immunological testing
Biological cellular material tested
C422S050000, C422S068100, C422S081000, C422S082000, C422S105000, C422S105000, C422S105000, C422S105000, C422S105000, C436S043000, C436S063000, C436S180000, C435S004000, C435S325000, C435S382000, C435S383000, C435S384000, C435S404000, C435S405000
Reexamination Certificate
active
07452726
ABSTRACT:
The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
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pat
Chou Hou-Pu
Daridon Antoine
Farrell Kevin
Fowler Brian
Liau Yish-Hann
Fluidigm Corporation
Sines Brian J
Townsend and Townsend / and Crew LLP
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