Microfluidic large scale integration

Fluid handling – Systems – Multiple inlet with multiple outlet

Reexamination Certificate

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C251S028000, C251S061100

Reexamination Certificate

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07143785

ABSTRACT:
High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

REFERENCES:
patent: 3570515 (1971-03-01), Kinner
patent: 3599525 (1971-08-01), Klann
patent: 3747628 (1973-07-01), Holster et al.
patent: 4046159 (1977-09-01), Pegourie
patent: 4119368 (1978-10-01), Yamazaki
patent: 4153855 (1979-05-01), Feingold
patent: 4245673 (1981-01-01), Bouteille et al.
patent: 4250929 (1981-02-01), Andreev et al.
patent: 4434704 (1984-03-01), Surjaatmadja
patent: 4898582 (1990-02-01), Faste
patent: 4992312 (1991-02-01), Frisch
patent: 5085562 (1992-02-01), Van Lintel
patent: 5088515 (1992-02-01), Kamen
patent: 5096388 (1992-03-01), Weinberg
patent: 5126115 (1992-06-01), Fujita et al.
patent: 5164558 (1992-11-01), Huff et al.
patent: 5171132 (1992-12-01), Miyazaki
patent: 5224843 (1993-07-01), Van Lintel
patent: 5259737 (1993-11-01), Kamisuki et al.
patent: 5265327 (1993-11-01), Faris et al.
patent: 5290240 (1994-03-01), Horres, Jr.
patent: 5336062 (1994-08-01), Richter
patent: 5346372 (1994-09-01), Naruse et al.
patent: 5375979 (1994-12-01), Trah
patent: 5376252 (1994-12-01), Ekstrom
patent: 5400741 (1995-03-01), DeTitta et al.
patent: 5423287 (1995-06-01), Usami et al.
patent: 5529465 (1996-06-01), Zengerle et al.
patent: 5593130 (1997-01-01), Hansson et al.
patent: 5642015 (1997-06-01), Whitehead et al.
patent: 5659171 (1997-08-01), Young et al.
patent: 5660370 (1997-08-01), Webster
patent: 5681024 (1997-10-01), Lisec et al.
patent: 5705018 (1998-01-01), Hartley
patent: 5759014 (1998-06-01), Van Lintel
patent: 5775371 (1998-07-01), Pan et al.
patent: 5788468 (1998-08-01), Dewa et al.
patent: 5836750 (1998-11-01), Cabuz
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5875817 (1999-03-01), Carter
patent: 5876187 (1999-03-01), Forster et al.
patent: 5932799 (1999-08-01), Moles
patent: 5942443 (1999-08-01), Parce et al.
patent: 6007309 (1999-12-01), Hartley
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6102068 (2000-08-01), Higdon et al.
patent: 6123769 (2000-09-01), Sanjoh
patent: 6155282 (2000-12-01), Zachary et al.
patent: 6174365 (2001-01-01), Sanjoh
patent: 6202687 (2001-03-01), Park
patent: 6296673 (2001-10-01), Santarsiero et al.
patent: 6345502 (2002-02-01), Tai et al.
patent: 6408878 (2002-06-01), Unger et al.
patent: 6409832 (2002-06-01), Weigl et al.
patent: 6767706 (2004-07-01), Quake et al.
patent: 2001/0027745 (2001-10-01), Weigl et al.
patent: 0 592 094 (1994-04-01), None
patent: 0 703 364 (1996-03-01), None
patent: 0 706 004 (1996-04-01), None
patent: 0 779 436 (1997-06-01), None
patent: 0 829 360 (1998-03-01), None
patent: 0 845 603 (1998-06-01), None
patent: 0 999 055 (2000-05-01), None
patent: 2 155 152 (1985-09-01), None
patent: 2 308 460 (1997-06-01), None
patent: WO 98/07069 (1998-02-01), None
patent: WO 99/00655 (1999-01-01), None
patent: WO 99/04361 (1999-01-01), None
patent: WO 99/17093 (1999-04-01), None
patent: WO 99/52633 (1999-10-01), None
patent: WO 00/00678 (2000-01-01), None
patent: WO 00/43748 (2000-07-01), None
patent: WO 00/60345 (2000-10-01), None
patent: WO 01/09595 (2001-02-01), None
patent: WO 01/09595 (2001-02-01), None
Unger M A et al. : “Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography” Science, American Association for the Advancement of Science, US, vol. 288, Apr. 7, 2000, pp. 113-116, XP002192277 ISSN: 0036-8075.
Thorsen, Todd: “Microfluidic technologies for high-throughput screening applications” (Online) Sep. 23, 2002 California Institute of Technology Pasadena, USA, XP002302465; Retrieved from the Internet: URL: http://resolver.caltech.edu/CaltechETD:etd-12012002-092026.
Todd Thorsen; Sebastian J. Maerkl, Stephen R. Quake: “Microfluidic Large-scale Integration” SCIENCE vol. 298, No. 5593 Oct. 18, 2002, pp. 580-584, XP002302473 Washington DC, USA.
“Biochips,” Nature Biotechnology, vol. 18, Supplement 2000, pp. IT43-IT44, 2000.
“Chapter 9: Microfluidic Devices,” Micromachined Transducers Sourcebook, pp. 779-882, 1998.
“Electro Microfluidic Dual In-Line Package (EMDIP),” Sandia National Laboratories, 2 pages, no date.
“Last Chance For Micromachines,” The Economist Technology Quarterly, printed from website http://www.economist.com/science/displayStory.cfm?Story—ID=442930 on Jan. 25, 2001, 8 pages, Dec. 7, 2000.
“The Liver Chip,” Technology Review, pp. 64-67, Mar. 2003.
Ahn, Chong H. et al., “Fluid Micropumps Based On Rotary Magnetic Actuators,” Proceedings of 1995 IEEE Micro Electro Mechanical Systems Workshop (MEMS '95), Amsterdam, Netherlands, pp. 408-412, Jan. 29-Feb. 2, 1995.
Anderson, Rolfe C. et al., “Microfluidic Biochemical Analysis System,” Transducers '97, 1997 International Conference on Solid-State Sensors and Actuators, Chicago, Illinois, pp. 477-480, Jun. 16-19, 1997.
Angell, James B. et al., “Silicon Micromechanical Devices,” Scientific American, pp. cover, 44-55, Apr. 1983.
Armani, Deniz et al., “Re-Configurable Fluid Circuits By PDMS Elastomer Micromachining,” IEEE Int. Conf. Micro Electro Mech. Syst. Tech. Digest, vol. 12, pp. 222-227, 1999.
Ashkin, A. et al., “Optical Trapping And Manipulation Of Single Cells Using Infrared Laser Beams,” Nature, vol. 330, No. 24, pp. 769-771, Dec. 31, 1987.
Ashkin, A. et al., “Optical Trapping And Manipulation Of Viruses And Bacteria,” Science, vol. 235, pp. 1517-1520, Mar. 20, 1987.
Ballantyne, J. P. et al., “Selective Area Metallization By Electron-Beam Controlled Direct Metallic Deposition,” J. Vac. Sci. Technol., vol. 10, No. 6, pp. 1094-1097, Nov. 1973.
Benard, W. L. et al., “A Titanium-Nickel Shape-Memory Alloy Actuated Micropump,” Transducers '97, 1997 International Conference on Solid-State Sensors and Actuators, Chicago, Illinois, pp. 361-364, Jun. 16-19, 1997.
Black, Harvey, “Tiny Technology Promises Tremendous Profits,” The Scientist, vol. 15, No. 21, 4 pages, Oct. 29, 2001.
Bloomstein, T. M. et al., “Laser-Chemical Three-Dimensional Writing For Microelectromechanics And Application To Standard-Cell Microfluidics,” J. Vac. Sci. Technol. B, vol. 10, No. 6, pp. 2671-2674, Nov. 1992.
Bousse, Luc et al., “Electrokinetically Controlled Microfluidic Analysis Systems,” Annu. Rev. Biophys. Biomol. Struct., vol. 29, pp. 155-181, 2000.
Brechtel, R. et al., “Control Of The Electroosmotic Flow By Metal-Salt-Containing Buffers,” Journal of Chromatography A, vol. 716, pp. 97-105, 1995.
Bryzek, Janusz et al., “Micromachines On The March”, IEEE Spectrum, vol. 31, No. 5, pp. 20-31, May 1994.
Buchaillot, Lionel et al., “Silicon Nitride Thin Films Young's Modulus Determination By An Optical Non Destructive Method,” Jpn. J. Appl. Phys., vol. 36, Part 2, No. 6B, pp. L794-L797, Jun. 15, 1997.
Buican, Tudor N. et al., “Automated Single-Cell Manipulation And Sorting By Light Trapping,” Applied Optics, vol. 26, No. 24, pp. 5311-5316, Dec. 15, 1987.
Burbaum, Jonathan J. et al., “New Technologies For High-Throughput Screening,” Current Opinion in Chemical Biology, vol. 1, pp. 72-78, 1997.
Cai, Weiwen, et al., “High-Resolution Restriction Maps Of Bacterial Artificial Chromosomes Constructed By Optical Mapping,” Proc. Natl

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