Microfluidic devices and uses thereof in biochemical processes

Details Microfluidic devices and uses thereof in biochemical processes Microfluidic devices and uses thereof in biochemical processes

2006-03-21

2006-03-21

Sisson, Bradley L. (Department: 1634)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S006120, C435S091100

Reexamination Certificate

active

07015030

ABSTRACT:
Provided is a microfluidic device comprising a microfluidic substrate comprising at least one pathway for sample flow; and at least one thermal transfer member which is capable of cycling between at least two temperatures. The thermal transfer member is adapted to heat at least a portion of the sample pathway while a sample is flowing along said at least a portion of said sample pathway. Provided also are methods of carrying out biochemical protocols using such a device.

REFERENCES:
patent: 5270183 (1993-12-01), Corbett et al.
patent: 5333675 (1994-08-01), Mullis et al.
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5508197 (1996-04-01), Hansen et al.
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5589136 (1996-12-01), Northrup et al.
patent: 5605662 (1997-02-01), Heller et al.
patent: 5716825 (1998-02-01), Hancock et al.
patent: 5716842 (1998-02-01), Baier et al.
patent: 5726026 (1998-03-01), Wilding et al.
patent: 5736314 (1998-04-01), Hayes et al.
patent: 5736614 (1998-04-01), Saito et al.
patent: 5779977 (1998-07-01), Haff et al.
patent: 5795976 (1998-08-01), Oefner et al.
patent: 5858804 (1999-01-01), Zanzucchi et al.
patent: 5866345 (1999-02-01), Wilding et al.
patent: 5872010 (1999-02-01), Karger et al.
patent: 6004744 (1999-12-01), Goelet et al.
patent: 6046056 (2000-04-01), Parce et al.
patent: 6054268 (2000-04-01), Perlin
patent: 6054277 (2000-04-01), Furcht et al.
patent: 6136212 (2000-10-01), Mastrangelo et al.
patent: 2001/0041357 (2001-11-01), Fouillet et al.
patent: 0820432 (1994-10-01), None
patent: 636 413 (1995-02-01), None
patent: 2 325 464 (1998-11-01), None
patent: WO 93/22058 (1993-11-01), None
patent: WO 96/15269 (1996-05-01), None
patent: WO 97/16561 (1997-05-01), None
patent: WO 98/22625 (1998-05-01), None
patent: WO 98/32535 (1998-07-01), None
patent: WO 98/45481 (1998-10-01), None
patent: WO 99/12016 (1999-03-01), None
patent: WO 99/17093 (1999-04-01), None
patent: WO 99/39005 (1999-08-01), None
patent: WO 99/41015 (1999-08-01), None
patent: WO 99/64848 (1999-12-01), None
patent: WO 00/23190 (2000-04-01), None
Kopp et al., “Chemical Amplification: Continuous-Flow PCR on a Chip,” Science, vol. 280, May 15, 1998, pp. 1046-1048.
Kopp et al., “Chemical Amplificaiton: Continuous-flow PCR on a Chip,” Science, vol. 280, May 15, 1998, pp. 1046-1048.
Kopp et al. “Continuous Flow PCR on a Chip,” Micro Total Analysis Systems, 1998, D.J. Harrison, A. van der Berg eds., Kluwer Academic Publishers, Dordrecht, pp. 7-10.
Poser et al., “Chip elements for fast thermocycling,” Sensors and Actuators A, vol. 62, 1997, pp. 672-675.
Kopp et al, SCIENCE, “Chemical amplification: continuous flow PCR on a chip”, vol. 280, pp1046-1048, May 15, 1998.
Woolley et al, Anal Chem, “Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device”, vol. 68, pp4081-4086, Dec. 1, 1996.
Ibrahim et al, Anal Chem, “Real-time microchip PCR for detecting single-base differences in viral and human DNA”, vol. 70, pp2013-2017, May 1, 1998.
Northrup et al, Anal Chem, “A miniature analytical instrument for nucleic acids based on micromachined silicon reaction chambers”, vol. 70, pp918-922, Mar. 1, 1998.
Cheng et al, Anal Biochem, “Degenerate oligonucleotide primed-polymerase chain reaction and capillary electrophoretic analysis of human DNA on microchip-based devices”, vol. 257, pp101-106, 1998.
Wilding et al, Clin Chem, “PCR in a silicon microstructure”, vol. 40, No. 9, pp1815-1818, 1994.
Daniel et al, Sensors and Actuators, “Silicon microchambers for DNA amplification”, vol. A 71, pp81-88, 1998.
Cheng et al, Nucleic Acids Res, “Chip PCR. II. Investigation of different PCR amplification systems in microfabricated silicon-glass chips”, vol. 24, No. 2, pp380-385, 1996.
Waters et al, Anal Chem, “Multiple sample PCR amplification and electrophoretic analysis on a microchip”, vol. 70, pp5172-5176, Dec. 15, 1998.
Hadd et al, Anal Chem, “Microchip device for performing enzyme assays”, vol. 69, pp3407-3412, Sep. 1, 1997.
Kopp et al, “Continuous flow PCR on a chip”, Micro Total Analysis Systems '98, D.J.Harrison, A.van den Berg, eds., Kluwer Academic Publishers, Dordrecht, pp7-10, 1998.
Aarts, H.J., et al., “High-resolution genotyping of Salmonella strains by AFLP-fingerprinting”,Lett. Appl. Microbiol.(1998), 26:131-5; PMID: 9569696.
Barany, F., “The Ligase Chaine reaction in a PCR World”,PCR Methods and Applications(1991), 1:5-16; Cold Spring Harbor Laboratory Press.
Bolla, M.K., et al., “Rapid determination of apolipoprotein E genotype using a heteroduplex generator”,J. Lipid Res.(1999), 40:2340-2345; PMID: 10588960.
Burns, M., et al., “An Integrated Nanoliter DNA Analysis Device”,Science(1998), 282:484-487.
Chevalier, M., et al., “Substrate Binding Induces Deploymerization of the C-terminal Peptide Binding Domain of Murine GRP78/BiP”,J. Biol. Chem.(1998), 273(41):26827-26835; The American Society for Biochemistry and Molecular Biology, Inc.
Goulding, J., et al., “Genome-Sequence-Based Fluorescent Amplified-Fragment Length Polymorphism Analysis ofMycobacterium tuberculosis”, J. Clin. Microbiol.(2000), 38(3):1121-1126; PMID: 10699006; American Society for Microbiology.
Gzyl, A., et al., “Technical aspects of random amplified polymorphic DNA (RAPD) technique in genotyping of bacterial strains”,Acta Microbiol. Pol.(1999), 48(3):243-59; PMID: 10756711.
Happ, G., et al., “DLA-DRB1 histocompatibilty genotyping using RT-nested PCR and cycle sequencing”,Vet. Immunol. Immunopathol.(1999), 69:93-100; PMID: 10507296; Elsevier Science B.V.
Harwood, C., et al., “Degenerate and Nested PCR: a Highly Sensitive and Specific Method for Detection of Human Pappillomavirus Infection in Cutaneous Warts”,J. Clin. Microbiol.(1999), 37(11):3545-3555; PMID: 10523550; American Society for Microbiology.
Hayashi, H., et al., “Temperature-dependent associating property of liposomes modified with a thermosensitive polymer”,Bioconjug Chem(1998), 9:382-9; PMID: 9576813; American Chemical Society.
Hookey, J.V., et al., “Use of Fluorescent amplified fragment length polymorphism (fAFLP) to characterize methicillin-resistantStaphylococcus aureus”,J. Microbiol. Meth.(1999), 37:7-15; Elsevier Science B.V.
Jensen, S.A., et al., “Domain 26 of tropoelastin plays a dominant role in association by coacervation”,J. Biol. Chem.(2000); PMID 10862774; The American Society for Biochemistry and Molecular Biology, Inc.
Jonas, D., et al., “Comparative Evaluation of Three Different Genotyping Methods for Investigation of Nosocomial Outbreaks of Legionnaires' Disease in Hospitals”,J. Clin. Microbiol.(2000), 38(6):2284-2291; PMID: 10834990; American Society for Microbiology.
Khandijan, E.W., “Heat Treatment induces dephosphorylation of pRb and dissociation of T-antigen/pRb complex during transforming infection with SV40”,Oncogene(1995), 10:359-367; Stockton Press.
Kishore, N., et al., “A thermodynamic investigation of reactions catalyzed by tryptophan synthase”,Biophys. Chem.(1998), 73:265-280; Elsevier Science B.V.
Kwok, P.-Y., et al., “Detection of Single Nucleotide Variations”,Genetic Engineering(1998), 20:125-134; PMID: 10395459; Plenum Press, New York.
Metcalfe, P., et al., “HPA Genotyping by PCR-SSP: Report of 4 Exercises”,Vox Sang.(1999), 77:40-43; PMID: 10474089; S. Karger AG, Basel, Switzerland.
Nelson, J.H., et al., “A novel and rapid PCR-based method for genotyping human papillomaviruses in clinical samples”,J. Clin. Microbiol.(2000), 38(2):688-95; PMID: 10655368; American Society for Microbiology.
Poser, S., et al., “Chip elements for fast thermocycling”,Sensors and Actuators(1997), A 62:672-675; Elsevier Science S

Affiliated with

Also associated with

Rating

Microfluidic devices and uses thereof in biochemical processes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microfluidic devices and uses thereof in biochemical processes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microfluidic devices and uses thereof in biochemical processes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3536265