Microfluidic device for enabling fluidic isolation among...

Details Microfluidic device for enabling fluidic isolation among... Microfluidic device for enabling fluidic isolation among...

2003-10-06

2008-09-02

Beisner, William H. (Department: 1797)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S297100, C435S297500, C435S288700, C435S305200, C422S105000, C422S105000

Reexamination Certificate

active

07419822

ABSTRACT:
Embodiments of the invention are directed to a device that combines microfabrication, microfluidic, and surface micropatterning techniques to create a multi-compartment neuronal culturing device that has application across a number of different neuroscience uses. Devices configured in accordance with the invention allow directed growth of neurites and isolation of neurites from their cell bodies. The device can use hydrostatic pressure to isolate insults to one compartment and, thus, expose localized areas of neurons to insults. Due to the high resistance of the microgrooves for fluid transport, insults are contained in the neuritic compartment without appreciable leakage into the somal compartment for a certain period of time (e.g., over 15 h).

REFERENCES:
patent: 5296375 (1994-03-01), Kricka et al.
patent: 5635396 (1997-06-01), Fedun
patent: 5744366 (1998-04-01), Kricka et al.
patent: 5773222 (1998-06-01), Scott
patent: 5830659 (1998-11-01), Stewart
patent: 5866345 (1999-02-01), Wilding et al.
patent: 6540895 (2003-04-01), Spence et al.
patent: 2002/0168757 (2002-11-01), Kirk et al.
patent: 2003/0003570 (2003-01-01), Kanegasaki et al.
patent: 2004/0005720 (2004-01-01), Cremer et al.

Affiliated with

Also associated with

Rating

Microfluidic device for enabling fluidic isolation among... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microfluidic device for enabling fluidic isolation among..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microfluidic device for enabling fluidic isolation among... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3992210