Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Miscellaneous laboratory apparatus and elements – per se
Reexamination Certificate
2007-11-08
2011-12-13
Bullock, In Suk (Department: 1772)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Miscellaneous laboratory apparatus and elements, per se
C422S417000, C422S068100, C435S287200, C435S287100, C435S007920, C436S501000, C436S518000
Reexamination Certificate
active
08075854
ABSTRACT:
A microfluidic chip comprises a substrate and a channel or multiple channels in the substrate. Each channel includes a tortuous path section or multiple tortuous path sections. A receptor for the detection of an analyte can be immobilized in a tortuous path section, for example by adsorption. Different receptors can be immobilized in different tortuous path sections of each channel or in different channels for simultaneous detection of multiple analytes. The chip is especially useful for running immunoassays, particularly ELISA.
REFERENCES:
patent: 6103199 (2000-08-01), Bjornson et al.
patent: 6610499 (2003-08-01), Fulwyler et al.
patent: 2002/0127740 (2002-09-01), Ho
patent: 2002/0176807 (2002-11-01), Gubernator et al.
patent: 2002/0187564 (2002-12-01), Chow et al.
patent: 2003/0027352 (2003-02-01), Hooper et al.
patent: 2003/0152934 (2003-08-01), Chang et al.
patent: 2003/0190608 (2003-10-01), Blackburn
patent: 2005/0097951 (2005-05-01), Hasselbrink et al.
patent: 2005/0277125 (2005-12-01), Benn et al.
patent: 2006/0286549 (2006-12-01), Sohn et al.
patent: 2007/0042427 (2007-02-01), Gerdes et al.
patent: 2007/0122819 (2007-05-01), Wu et al.
patent: 2008/0273918 (2008-11-01), Linder et al.
patent: 2009/0079976 (2009-03-01), Cunningham et al.
Bai et al., “Surface Modification for Enhancing Antibody Binding on Polymer-Based Microfluidic Device for Enzyme-Linked Immunosorbent Assay”,Langmuir, 2006, 22, 9458-9467, American Chemical Society.
Call et al., “Detecting and genotypingEscherichia coliO57:H7 using multiplexed PCR and nucleic acid microarrays”,International Journal of Food Microbiology, 67 (2001) 71-80, Elsevier Science B.V.
Carbonaro et al., “A resistive-pulse sensor chip for multianalyte immunoassays”,Lab Chip, 2005, 5, 1155-1160, The Royal Society of Chemistry 2005.
Chen et al., “Simultaneous detection ofEscherichia coliO157:H7,Salmonellaspp. andListeria monocytogeneswith an array-based immunosorbent assay using universal protein G-liposomal nanovesicles”,Talanta, 69 (2006) 232-238, Science Direct, Elsevier B.V.
Du et al., “Parallel Detection and Quantification Using Nin Immunoassays in a Protein Microarray for Drug from Serum Samples”,Biomedical Microdevices, 7:2, 143-146, 2005, Springer Science + Business Media, Inc., Netherlands.
Dunbar et al., “Quantitative, multiplexed detection of bacterial pathogens: DNA and protein applications of the Luminex LabMAP™ system”,Journal of Microbiological Methods, 53 (2003) 245-252, Elsevier Science B.V.
Eteshola et al., “Development and characterization of an ELISA assay in PDMS microfluidic channels”,Sensors and Actuators B, 72 (2001) 129-133, Elsevier Science B.V.
Kartalov et al., “High-throughput multi-antigen microfluidic fluorescence immunoassays”,Bio Techniques, 40:85-90 (Jan. 2006), vol. 40, No. 1 (2006).
Liew et al., “Validating a custom multiplex ELISA against individual commercial immunoassays using clinical samples”,BioTechniques, 42:327-333 (Mar. 2007), vol. 42, No. 3, 2007.
Lopez et al., “Innovative tools for detection of plant pathogenic viruses and bacteria”,Int Microbiol(2003) 6:233-343.
Mendoza et al., “High-Throughput Microarray-Based Enzyme-Linked Immunosorbent Assay (ELISA)”,Bio Techniques, 27:778-788 (Oct. 1999), vol. 27, No. 4 (1999).
Moss et al., “Detection ofCryptosporidiumAntibodies in Sera and Oral Fluids Using Multiplex Bead Assay”,J. Parasitol., 90(2), 2004, pp. 397-404, American Society of Parasitologists 2004.
Khan et al., “Simultaneous Serodetection of 10 Highly Prevalent Mouse Infectious Pathogens in a Single Reaction by Multiplex Analysis”,Clinical and Diagnostic Laboratory Immunology, Apr. 2005, p. 513-519.
Micheli et al., “Electrochemical immunosensor array using a 96-well screen-printed microplate for aflatoxin B1detection”,Biosensors and Bioelectronics, 22 (2007) 1434-1440, Elsevier.
Rowe-Taitt et al., “Simultaneous detection of six biohazardous agents using a planar waveguide array biosensor”, Biosensors and Bioelectronics, 15 (2000) 579-589, Elsevier.
Sato et al., “Microchip-based enzyme-linked immunosorbent assay (microELISA) system with thermal lens detection”,Lab Chip, 2004, 4, 570-575, The Royal Society of Chemistry.
Situma et al., “Merging microfluidics with microarray-based bioassays”,Biomolecular Engineering, 23 (2006) 213-231, Elsevier B.V.
Kim et al., “Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel”,Lab Chip, 2005, 5, 657-664, The Royal Society of Chemistry.
Wolf et al., “Simultaneous detection of C-reactive protein and other cardiac markers in human plasma using micromosaic immunoassays and self-regulating microfluidic networks”,Biosensors and Bioelectronics, 19 (2004) 1193-1202, Elsevier B.V.
Zaytseva, et al., “Development of a microfluidic biosensor module for pathogen detection”,Lab Chip, 2005, 5, 805-811, The Royal Society of Chemistry.
Zhang et al., “An AntiE. ColiO157:H7 Antibody-Immobilized Microcantilever for the Detection ofEscherichia Coli(E. coli)”,Analytical Sciences, Apr. 2004, vol. 20, 585-587, The Japan Society for Analytical Chemistry.
Jani et al., “Multiplexed immunoassays by flow cytometry for diagnosis and surveillance of infectious diseases in resource-poor settings”,The Lancet, Infectious Diseases, vol. 2, Apr. 2002, 243-250.
Kuller et al., “Development of whole-virus multiplex flow cytometric assay for antibody screening of a specific pathogen-free primate colony”,Diagnostic Microbiology and Infectious Disease, 53 (2005) 185-193, Elsevier.
Lash et al., “Comparison of three multiplex cytokine analysis systems: Luminex, SearchLight™ and FAST Quant®”,Journal of Immunological Methods, 309 (2006) 205-208, Elsevier B.V.
Mead et al., “Food-Related Illness and Death in the United States”,Emerging Infectious Diseases, vol. 5, No. 5, Sep.-Oct. 1999, Centers for Disease Control and Prevention, Atlanta, GA.
Rao et al., “Comparison of Multiplexed Techniques for Detection of Bacterial and Viral Proteins”,Journal of Proteome Research, 2004, 3, 736-742, American Chemical Society.
Ray et al., “Development, validation, and implementation of a multiplex immunoassay for the simultaneous determination of five cytokines in human serum”,Journal of Pharmaceutical and Biomedical Analysis, 36 (2005) 1037-1044,Elsevier B.V.
Rowe et al., “Array Biosensor for Simultaneous Identification of Bacterial, Viral, and Protein Analytes”,Anal. Chem., 1999, 71, 3846-3852, American Chemical Society.
Philipp Angenendt, “Progress in protein and antibody microarray technology”,DDT, vol. 10, No. 7, Apr. 2005, pp. 503-511, Elsevier Ltd.
Angenendt et al., “3D Protein Microarrays: Performing Multiplex Immunoassays on a Single Chip”,Anal. Chem., 2003, 75, 4368-4372, American Chemical Society.
Ayriss et al., “High-Throughput Screening of Single-Chain Antibodies Using Multiplexed Flow Cytometry”,Journal of Proteome Research, 2007, 6, 1072-1082, American Chemical Society.
Bai et al., “Enzyme-Linked Immunosorbent Assay ofEscherichia coliO157:H7 in Surface Enhanced Poly(Methyl Methacrylate) Microchannels”,Biotechnology and Bioengineering, vol. 98, No. 2, Oct. 1, 2007, Wiley Periodicals, Inc.
Bernard et al., “Micromosaic Immunoassays”,Anal. Chem., 2001, 73, 8-12, American Chemical Society.
Cui et al., “Rapid sample preparation method for PCR-based detection ofEscherichia coliO157:H7 in ground beef”,Journal of Applied Microbiology, 2003, 95, 129-134, The Society for Applied Microbiology.
De Jager et al., “Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies”,Journal of Immuno
Bai Yunling
Huang Wei-Cho
Yang Shang-Tian
Bullock In Suk
Fay Sharpe LLP
Kingan Timothy G
The Ohio State University Research Foundation Bioprocessing Inno
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