Microfluidic chip for biomolecule crystallization

Details Microfluidic chip for biomolecule crystallization Microfluidic chip for biomolecule crystallization

2005-02-01

2005-02-01

Gakh, Yelena G. (Department: 1743)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C436S004000, C436S176000, C436S178000

Reexamination Certificate

active

06849459

ABSTRACT:
A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.

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