Microfluidic chip apparatuses, systems and methods having...

Optics: measuring and testing – Sample – specimen – or standard holder or support – Fluid containers

Reexamination Certificate

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Reexamination Certificate

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07933012

ABSTRACT:
According to one embodiment, apparatuses and methods are provided for connecting a light-guiding conduit to a microfluidic channel. First and second substrates with first surfaces can be provided, wherein the first surfaces of the first and second substrates form a microfluidic channel and a connection channel when the first surfaces are positioned together, and wherein the connection channel extends from an edge of the first surface of the first or second substrate to the microfluidic channel. The apparatus and method can also include bonding the first surfaces of the first and second substrates to form the microfluidic channel and the connection channel. A light-guiding conduit can be inserted into the connection channel such that the light-guiding conduit connects to the microfluidic channel and filling an area between the light-guiding conduit and the connection channel for forming a liquid-tight seal between the light-guiding conduit and the connection channel.

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PCT/US06/31164 Written Opinon of the International Searching Authority dated Dec. 21, 2007.
PCT/US06/31164 International Preliminary Report of Patentability dated Mar. 26, 2009.
Bings, N.H. et al., “Microfluidic Devices Connected to Fused-Silica Capillaries with Minimal Dead Volume,” Anal. Chem., 1999, vol. 71, pp. 3292-3296.
Galambos, P. et al., “Precision Alignment Packaging for Microsystems With Multiple Fluid Connections,” Proceedings of 2001 Amer. Soc. Mech. Eng., Nov. 11-16, 2001, 8 pages.

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