Microfabricated tissue as a substrate for pigment epithelium...

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Eye prosthesis

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C623S006630, C623S002160

Reexamination Certificate

active

06939378

ABSTRACT:
Methods and apparatus for modifying membranous tissue, growing cells on modified membranous tissue, and for transplantation of modified tissues and modified tissues with attached cells are provided. In particular, the invention provides methods and apparatus for modifying membranous tissue such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial (IPE) cells and retinal pigment epithelial (RPE) cells on modified membranous tissue, and for modifying membranous tissue and growing cells on biodegradable polymer substrates. A method of modifying membranous tissues comprises depositing micropatterns of biomolecules onto membranous tissue with a contacting surface such as a stamp; other methods include mechanical ablation, photoablation, ion beam ablation, and modification of membranous tissues via the action of proteolytic enzymes.

REFERENCES:
patent: 5962027 (1999-10-01), Hughes
patent: 6045791 (2000-04-01), Liu
L. Lu, et al., “Retinal pigment epithelium cell culture on thin biodegradable poly(DL-lactic-co-glycolic acid) films”, J. Biomater Science Edn. vol. 9, No. 11 pp. 1187-1205 (1998).
T. Dintelmann, et al., “Comparative study of ROS degradation by IPE and RPE cells in vitro”, Graefe's Arch Clin. Exp. Ophthalmology 1999 No. 237 pp 830-839.
C.D. James, et al., “Aligned Microcontact Printing of Micrometer-Scale Poly-L-Lysine Structures for Controlled Growth of Cultured Neurons on Planar Microelectrode Arrays”, IEEE Transaction On Biomedical Engineering, vol. 47, No. 1, Jan. 200, pp 17-21.
U. Hartmann, et al., “Human and porcine anterior lens capsule as support for growing and grafting retinal pigment epithelium and iris pigment epithelium”, Graefe's Arch Clin Exp Ophthalmoloy (1999), vol. 237, pp 940-945.
G. Thumann, et al., Transplantation of Autologous Iris Pigment Epithelium After Removal of Choroidal Neovascular Membranes, Arch Ophthalomology (Oct. 2000), vol. 118, pp. 1350-1355.
L. Lu, et al., “Retinal pigment epithelial cell function on substrates with chemically micropatterned surfaces”, Biomaterials (Dec. 1999), vol. 20 No. 23/24, pp. 2351-2361.
A. Lappas, et al., “Cilinical investigation: Iris pigment epithelial cell translocation in exudative age-related mascular degeneration, A pilot study in patients”, Graefe's Archive for Clinical Experimental Opthalmology, Abstract, vol. 238 issue, p. 1 and 2 electronic version, ISSN: 1435-702X, http://link.springer-ny.com/link/service/journals/00417/bibs/0238008/02380631.htm.
Giordano, et al., “Retinal pigment epithelium cells cultured on synthetic biodegradable polymers”, (Abstract), http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=897 . . . 6.
Abe T., et al., “Auto iris pigment epithelial cell transplantation in patients with age-related mascular degeneration: short-term results”, (Abstract), http://www.n . . . /query.fcgi?cmd=Retrieve&dblist=PubMed&list_uids=10896035&dopt=Abstrac.
Abe T., et al., “Functional analysis after auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration”, (Abstract), http://www.n . . . /query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10739165&dopt=Abstrac.
Nicolini, et al., “The anterior lens capsule used as support material in RPE cell-transplantation”, (Abstract), http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11C . . . 7.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Microfabricated tissue as a substrate for pigment epithelium... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microfabricated tissue as a substrate for pigment epithelium..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microfabricated tissue as a substrate for pigment epithelium... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3436277

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.