Chemistry: molecular biology and microbiology – Apparatus – Including condition or time responsive control means
Patent
1995-06-06
1997-10-07
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Including condition or time responsive control means
4352872, 4352883, 4352885, 422102, 417322, 4174133, C12M 136, C12M 138
Patent
active
056747420
ABSTRACT:
An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of the instrument provides accurate, contamination-free processing. The instrument may include reagent reservoirs, agitators and mixers, heaters, pumps, and optical or electromechanical sensors. Ultrasonic Lamb-wave devices may be used as sensors, pumps and agitators.
REFERENCES:
patent: 2127193 (1938-08-01), Toulmin
patent: 3029743 (1962-04-01), Johns
patent: 4219335 (1980-08-01), Ebersole
patent: 4556467 (1985-12-01), Kuhn et al.
patent: 4596697 (1986-06-01), Ballato
patent: 4598049 (1986-07-01), Zelinka et al.
patent: 4602184 (1986-07-01), Meitzler
patent: 4632808 (1986-12-01), Yamamoto et al.
patent: 4673657 (1987-06-01), Christian
patent: 4676274 (1987-06-01), Brown
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4692654 (1987-09-01), Umemura et al.
patent: 4708931 (1987-11-01), Christian
patent: 4737464 (1988-04-01), McConnell et al.
patent: 4759828 (1988-07-01), Young et al.
patent: 4908112 (1990-03-01), Pace
patent: 4920056 (1990-04-01), Dasgupta
patent: 4952266 (1990-08-01), Tsuruta et al.
patent: 4960486 (1990-10-01), Perkins et al.
patent: 4963498 (1990-10-01), Hillman et al.
patent: 5000817 (1991-03-01), Aine
patent: 5003822 (1991-04-01), Joshi
patent: 5006749 (1991-04-01), White
patent: 5129262 (1992-07-01), White et al.
patent: 5153476 (1992-10-01), Kosinski
patent: 5212988 (1993-05-01), White et al.
patent: 5220189 (1993-06-01), Higashi et al.
patent: 5229297 (1993-07-01), Schnipelsky et al.
patent: 5252294 (1993-10-01), Kroy et al.
patent: 5270183 (1993-12-01), Corbett et al.
patent: 5296375 (1994-03-01), Kricka et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5384029 (1995-01-01), Campbell
patent: 5385709 (1995-01-01), Wise et al.
patent: 5427946 (1995-06-01), Kricka et al.
patent: 5486335 (1996-01-01), Wilding et al.
patent: 5498392 (1996-03-01), Wilding et al.
Andle, J. et al., "Detection of Nucleic Acid Hybridization with an Acoustic Plate Mode Microsensor," IEEE Ultrasonics Symposium, vol. 1, Honolulu, Hawaii, Dec. 4-7, 1990, pp. 291-294.
Angell, James B., et al., "Silicon Micromechanical Devices," Scientific American, (Apr. 1983) vol. 248, No. 4, pp. 44-55.
Backman, Keith, "Ligase Chain Reaction: Diagnostic Technology for the 1990s and Beyond," Clinical Chemistry, (1992) vol. 38, No. 3, pp. 457-458.
Erlich, Henry A., ed., "PCR Technology, Principles and Applications for DNA Amplications, " PCR Technology M Stockton Press, (1989) pp. 32-38.
Esashi, Masayoshi, et al., "Integrated Flow Control Systems Fabricated on a Silicon Wafer,"Proceedings, Electrochemical Society Conference, III (18-23 Oct. 1987) Electrochemical Society, Pennington, N.J. pp. 31-38B.
Fromberz, Peter, et al., "Core-coat conductor of lipid bilayer and micromachined silicon," Biochemica et Biophysica Acta, (1991) vol. 1062, pp. 103-107.
Gibbs, Richard A., "DNA Amplification by the Polymerase Chain Reaction," Analytical Chemistry, (Jul. 1, 1990) vol. 62, No. 13, pp. 1202-1214.
Heller, M. J., et al., "An Efficient Method for Extraction of DNA from Formalin-Fixed, Paraffin-Embedded Tissue by Sonication," BioTechniques, (1991) Research Report, vol. 11, No. 3, pp. 372-377.
Higuchi, Russel, et al., "Simulaneous Amplification and Detection of Specific DNA Sequences," Biotechnology, (Apr. 1992), vol. 10, pp. 413-417.
Hoopman, Timothy L., "Microchanneled Structures," Microstructures, Sensors and Actuators, (1990) Cho, et al. Eds. The American Society of Mechanical Engineers (4 pages).
Howe, Roger T., et al., "Resonant-Microbridge Vapor Sensor," IEEE Transactions on Electron Devices, (Apr. 1986) vol. ED-33, No. 4, pp. 499-506.
Howe, R.T., et al., "Silicon Micromechanics: sensors and actuators on a chip," IEEE Spectrum, Jul. 1990, pp. 29-35.
Kawasaki, Ernest S., "Sample Preparation from Blood, Cells, and Other Fluids," PCR Protocols, A Guide to Methods and Applications, (1990) Innis, Michael A., et al., ed., Academic Press, Inc., Chapter 18, pp. 146-149.
Kricka, et al., "Liquid Transport in Micron and Submicron Channels," SPIE, 1167:159-168 (1989).
Mandenius, Carl Fredrik, et al., "The Interaction of Proteins and Cells with Affinity Ligands Covalently Coupled to Silicon Surfaces as Monitored by Ellipsometry," Analytical Biochemistry, (1984) vol. 137, pp. 106-114.
Manz, A., et al., "Micromachining of monocrystalline silicon and glass for chemical analysis systems," Trends in Analytical Chemistry, (1991) vol. 10, No. 5, pp. 144-149.
Masuda, Senichi, et al., "Novel Method of Cell Fusion in Field Constriction Area in Fluid Integrated Circuit," Proceedings IEEE/IAS Meeting, (1987) pp. 1549-1553.
Oste, Christian, "Polymerase Chain Reaction," BioTechniques, (1988) vol. 6, pp. 162-167.
Parce, J. Wallace, et al., "Detection of Cell-Affecting Agents with a Silicon Biosensor," Science, (Oct. 13, 1989) vol. 24, pp. 243-247.
Pfahler, P., et al., "Liquid Transport in Micron and Submicron Channels," Sensors & Actuators, (1990) pp. 431-434.
Sato, Kazuo, et al., "Individual and Mass Operation of Biological Cells using Micromechanical Silicon Devices," Sensors and Actuators, (1990) A21-A23:948-953.
Senturia, Stephen D., et al., Section 2.5: Microprocessor Packaging, (Paper presented at the 14th Automotive Materials Conference, Ann Arbor, MI, U.S.A. Nov. 19, 1986, pp. 185-191.) Reprinted with permission from Sensors and Actuators, vol. 15, pp. 221-234, Nov. 1988.
Shoji, Shuichi, et al. "Prototype Miniature Blood Gas Analyser Fabricated on a Silicon Wafer," Sensors and Actuators (1988), vol. 15 pp. 101-107.
Sundaram, Mani, et al., "New Quantum Structures," Science, Nov. 29, 1991, vol. 254, pp. 1326-1335.
Van Lintel, H.T.G., et al., "A Piezoelectric Micropump Based on Micromachining of Silicon," Sensors and Actuators, 15 (1988) pp. 153-167.
Vossen, John L., et al. "Thin Film Processes," Copyright 1978 Academic Press, Inc., Chapter I-1, p. 5 and Chapter III-2, p. 309.
Washizu, Masao, et al., "Handling of Biological Cells Using Fluid Integrated Circuit," Proceedings IEE/IAS Meeting, (1988) pp. 1735-1740.
Wenzel, Stuart T., et al., "A Multisensor Employing an Ultrasonic Lamb-Wave Oscillator," IEEE Transactions on Electron Devices, Jun. 1988, vol. 35, No. 6, pp. 735-743.
Whitesides, George M., "Molecular Self-Assembly and Nanochemistry: A Chemical Strategy for the Synthesis of Nanostructures," Science, vol. 254, pp. 1312-1319. (Nov. 1991).
Wise, K.D., et al., "Microfabrication Techniques for Integrated Sensors and Microsystems," Science, (Nov. 29, 1991) vol. 254, pp. 1335-1342.
Wittwer, Cart T., et al., "Minimizing the Time Required for DNA Amplification by Efficient Heat Transfer to Small Samples," Analytical Biochemistry, (1990) vol. 186, pp. 328-331.
Northrup M. Allen
White Richard M.
Beisner William H.
The Regents of the University of California
LandOfFree
Microfabricated reactor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microfabricated reactor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microfabricated reactor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2356445