Microfabricated reactor

Liquid heaters and vaporizers – Fire tube – Horizontal or inclined

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

56345, 422 681, 4352831, 4352851, 4352865, 435287, 4352871, 4352873, 4352876, 435288, 4352891, 4352892, 4352883, 4352884, 435391, 4353021, 4353052, 4353063, 4353053, 435316, G01N 3348

Patent

active

056394233

ABSTRACT:
An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of the instrument provides accurate, contamination-free processing. The instrument may include reagent reservoirs, agitators and mixers, heaters, pumps, and optical or electromechanical sensors. Ultrasonic Lamb-wave devices may be used as sensors, pumps and agitators.

REFERENCES:
patent: 4219335 (1980-08-01), Ebersole
patent: 4596697 (1986-06-01), Ballato
patent: 4598049 (1986-07-01), Zelinka et al.
patent: 4632808 (1986-12-01), Yamamoto et al.
patent: 4673657 (1987-06-01), Christian
patent: 4676274 (1987-06-01), Brown
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4708931 (1987-11-01), Christian
patent: 4737464 (1988-04-01), McConnell et al.
patent: 4759828 (1988-07-01), Young et al.
patent: 4908112 (1990-03-01), Pace
patent: 4920056 (1990-04-01), Dasgupta
patent: 4952266 (1990-08-01), Tsuruta et al.
patent: 4960486 (1990-10-01), Perkins et al.
patent: 4963498 (1990-10-01), Hillman et al.
patent: 5000817 (1991-03-01), Aine
patent: 5003822 (1991-04-01), Joshi
patent: 5006749 (1991-04-01), White
patent: 5129262 (1992-07-01), White et al.
patent: 5212988 (1993-05-01), White
patent: 5220189 (1993-06-01), Higashi et al.
patent: 5229297 (1993-07-01), Schnipelsky et al.
patent: 5252294 (1993-10-01), Kroy et al.
patent: 5270183 (1993-12-01), Corbett et al.
patent: 5296375 (1994-03-01), Kricka et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5385709 (1995-01-01), Wise et al.
patent: 5427946 (1995-06-01), Kricka et al.
patent: 5486335 (1996-01-01), Wilding et al.
patent: 5498392 (1996-03-01), Wilding et al.
Esqshi et al., "Integrated Flow Control Systems Fabricated on a Silicon Wafer", Proceedings Electrochemical Society Conf. III Oc. 18-23, 1987, pp. 31-38B.
Masuda et al., "Novel Method of Cell Fusion in a Fluid Constriction Area in Fluid Integrated Circuit," Proc. IEEE/IAS Meeting (1987), pp. 1549-1553.
Pfahler et al., "Liquid Transport in Micron & Submicron Channels", Sensors & Actuators, (1990), pp. 431-434.
Backman, Keith, "Ligase Chain Reaction: Diagnostic Technology for the 1990s and Beyond," Clinical Chemistry, (1992) vol. 38, No. 3, pp. 457-458.
Erlich, Henry A., ed., "PCR Technology, Principles and Applications for DNA Amplification," PCR Technology M Stockton Press, (1989) pp. 32-38.
Fromberz, Peter, et al., "Core-coat conductor of lipid bilayer and micromachined silicon," Biochemica et Biophysica Acta. (1991) vol. 1062, pp. 103-107.
Higuchi, Russel, et al., "Simultaneous Amplification and Detection of Specific DNA Sequences," Biotechnology, (Apr. 1992), vol. 10, pp. 413-417.
Hoopman, Timothy L., "Microchanneled Structures," Microstructures, Sensors and Actuators, (1990) Cho, et al. Eds. The American Society of Mechanical Engineers (4 pages).
Howe, Roger T., et al., "Resonant-Microbridge Vapor Sensor," IEEE Transactins on Electron Devices, ED33:499-506 (1986).
Kawasaki, Ernest S., "Sample Preparation from Blood, Cells, and Other Fluids," PCR Protocols, A Guide to Methods and Applications, (1990) Innis, Michael A., et al., ed., Academic Press, Inc., Chapter 18, pp. 146-149.
Kricka, et al., "Liquid Transport in Micron and Submicron Channels," SPIK, 1167:159-168 (1989).
Mandenius, Carl Fredrik, et al., "The Interaction of Proteins and Cells with Affinity Ligands Covalently Coupled to Silicon Surfaces as Monitored by Ellipsometry," Analytical Biochemistry, (1984) vol. 137, pp. 106-114.
Manz, A., et al., "Micromachining of monocrystalline silicon and glass for chemical analysis systems," Trends in Analytical Chemistry, (1991) vol. 10, No. 5, pp. 144-149.
Oste, Christian, "Polymerase Chain Reaction," BioTechniques, (1988) vol. 6, pp. 162-167.
Parce, J. Wallace, et al., "Detection of Cell-Affecting Agents with a Silicon Biosensor," Science, (Oct. 13, 1989) vol. 24, pp. 243-247.
Sato, Kazuo, et al. "Individual and Mass Operation of Biological Cells using Micromechanical Silicon Devices," Sensors and Actuators, (1990) A21-A23:948-953.
Shoji, Shuichi, et al. "Prototype Miniature Blood Gas Analyser Fabricated on a Silicon Wafer," Sensors and Actuators (1988), vol. 15 pp. 101-107.
Van Lintel, H.T.G., et al., "A Piezoelectric Micropump Based on Micromachining of Silicon," Sensors and Actuators, 15 (1988) pp. 153-167.
Vossen, John L., et al. "Thin Film Processes," Copyright 1978 Academic Press, Inc., Chapter I-1, p. 5 and Chapter III-2, p. 309.
Washizu, Masao, et al., "Handling of Biological Cells Using Fluid Integrated Circuit," Proceedings IEE/IAS Meeting, (1988) pp. 1735-1740.
Whitesides, George M., "Molecular Self-Assembly and Nanochemistry: A Chemical Strategy for the Synthesis of Nanostructures," Science, vol. 254, pp. 1312-1342.
Andle, J. et al., "Detection of Nucleic Acid Hybridization with an Acoustic Plate Mode Microsensor," IEEE Ultrasonics Symposium, vol. 1, Honolulu, Hawaii, Dec. 4-7, 1990, pp. 291-294.
Angell, J.B. et al., "Silicon Micromechanical Devices", Scientific American, vol. 248, No. 4, Apr. 1983, pp. 44-55.
Howe, R.T. et al., "Silicon Micromechanics: Sensors and Actuators on a Chip", IEEE Spectrum, Jul. 1990, pp. 29-35.
Wenzel, S.T. et al., "A Multisensor Employing an Ultrasonic Lamb-Wave Oscillator", IEEE Transactions on Electron Devices, vol. 35, No. 6, Jun. 1988, pp. 735-743.
K. Wise and K. Najafi, "Microfabrication Techniques for Integrated Sensors and Microsystems", Science, vol. 254, Nov. 29, 1991, pp. 1335-1342.
C. Wittwer et al., "Minimizing the Time Required for DNA Amplicication by Efficient Heat Transfer to Small Samples", Analytical Biochemistry, 186, 1990, pp. 328-331.
R. Gibbs, "DNA Amplification by the Polymerase Chain Reaction", Analytical Chemistry, vol. 62, No. 13, Jul. 1, 1990, pp. 1202-1214.
M. Heller et al., Biotechniques, vol. 11, No. 3, 1991, pp. 372-377.
R. White, U.S. Patent Application No. 07/162,193, Feb. 29, 1988 (abandoned) .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Microfabricated reactor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microfabricated reactor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microfabricated reactor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2155666

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.