Microfabricated flowthrough porous apparatus for discrete...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007920, C435S973000, C436S518000, C436S527000, C436S809000, C428S426000

Reexamination Certificate

active

07125674

ABSTRACT:
An improved apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through a substrate and terminate on a second surface thereof, such that when a test sample is applied to the substrate, it is capable of penetrating through each such region during the course of the binding reaction. The apparatus is especially useful for sequencing by hybridization of DNA molecules.

REFERENCES:
patent: 4693985 (1987-09-01), Degen et al.
patent: 4713347 (1987-12-01), Mitchell et al.
patent: 4797259 (1989-01-01), Matkovich et al.
patent: 4874691 (1989-10-01), Chandler
patent: 4888414 (1989-12-01), Knutson
patent: 4916056 (1990-04-01), Brown, III et al.
patent: 5077210 (1991-12-01), Eigler et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5188733 (1993-02-01), Wang et al.
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5231035 (1993-07-01), Akers, Jr.
patent: 5234594 (1993-08-01), Tonucci et al.
patent: 5244815 (1993-09-01), Guirguis
patent: 5310686 (1994-05-01), Sawyers et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5516644 (1996-05-01), Yamauchi et al.
patent: 5552270 (1996-09-01), Khrapko et al.
patent: 5554501 (1996-09-01), Coassin et al.
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5585968 (1996-12-01), Guhman et al.
patent: 5677195 (1997-10-01), Winkler et al.
patent: 5723344 (1998-03-01), Mabilat et al.
patent: 5763263 (1998-06-01), Dehlinger
patent: 5807755 (1998-09-01), Ekins
patent: 5843767 (1998-12-01), Beattie
patent: 5846708 (1998-12-01), Hollis et al.
patent: 6268128 (2001-07-01), Collins et al.
patent: 38 01 987 (1989-07-01), None
patent: 0 347 579 (1989-12-01), None
patent: 0 505 632 (1992-09-01), None
patent: 2197720 (1988-05-01), None
patent: WO 89/01157 (1989-02-01), None
patent: WO 89/10977 (1989-11-01), None
Maskos, U. and Southern, E. (Nucleic Acids Research)vol. 21, No. 9, pp. 2269-2270 (1993).
Ekins (1989). Multi-analyte immunoassay. J. Pharm. Blomed. Anal. 7(2):155-168.
Ekins et al. (1989). Development of microspot multi-analyte ratiometric immunoassay using dual fluorescent-labelled antibodies. Analytical Chimica Acta 227:73-96.
Ekins et al. (1991). Multianalyte microspot immunoassay—Micro “compact disk” of the future. Clin. Chem. 17(11):1955-1967.
Kenneth Beattie et al., “Genosensor Technology,” Clinical Chemistry 39:719-722 (1993).
Drmanac et al., “Sequencing by Hybridization: Towards an Automated Sequencing of one Million M1 Clones Arrayed on Membrane,” Electrophoresus 13:566-573 (1992).
Mitchell D. Eggers et al., “Genosensors: Microfabricated Devices for Automated DNA Sequence Analysis,” Advances in DNA Sequencing Technology 1891, Proceedings Repring, SPIE (1993).
Sebastian Meier-Ewart et al., “An Automated Approach to Generating Expressed Sequence Catalogues,” Nature 361:375-376 (1993).
K. R. Khrapko et al., “Method for DNA Sequencing by Hybridization with Oligonucleotide Matrix,”J.DNA Sequencing and Mapping 1:375-388 (1991).
Gjermund Kittilsland et al., “A Sub-Micron Particle Filter in Silicon,” Sensors and Actuators A21-A23 904-907 (1990).
Randall K. Salki et al., “Genetic Analysis of Amplified DNA with Immobilized Sequenced-Specific Oligonucleotode Probes,” Proc. Natl. Acad. Sci USA 86:6230-6234 (1989).
E. M. Southern, “Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides: Evaluation Using Experimental Models,” Genomics 13:1008-1017 (1992).
R. J. Tonucci et al., “Nanochannel Array Glass,” Science 258:783-785 (1992).
Drmanac, R. et al., “DNA Sequence Determination by Hybridization: A Strategy for Efficient Large-Scale Sequencing,”Science260:1649-1652 (1993).
Parham et al “Carboxyl--terminal Sequential Deradation of Peptides” BBRC vol. 80, No. 1 pp. 1-6, 1978.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Microfabricated flowthrough porous apparatus for discrete... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microfabricated flowthrough porous apparatus for discrete..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microfabricated flowthrough porous apparatus for discrete... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3691230

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.