Microfabricated, flowthrough porous apparatus for discrete...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C422S068100, C422S069000, C435S007100, C435S007200, C435S007800, C435S287100, C435S287200, C435S287400, C435S970000, C435S973000, C436S501000, C436S518000, C436S527000, C436S535000, C436S805000, C436S807000, C436S808000, C436S809000

Reexamination Certificate

active

06893816

ABSTRACT:
An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a second surface thereof such that when a test sample is applied to the substrate, it is capable of penetrating through each such region during the course of said binding reaction. The apparatus is especially useful for sequencing by hybridization of DNA molecules.

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