Microfabricated apparatus for cell based assays

Details Microfabricated apparatus for cell based assays Microfabricated apparatus for cell based assays

2008-09-23

2011-10-04

Beisner, William H (Department: 1775)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S288700, C435S297500, C422S415000, C422S072000, C422S506000

Reexamination Certificate

active

08030062

ABSTRACT:
Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel and an outlet channel, a cover plate positioned over the base plate to define the chambers and connecting channels. Means are incorporated in the cell growth chambers, for cell attachment and cell growth. In particular, the invention provides a rotatable disc microfabricated for performing cell growth and cell based assays. The apparatus and method can be used for the growth of cells and the detection and measurement of variety of biochemical processes and products using non-invasive techniques, that is techniques which do not compromise the integrity or viability of cells.

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