Microencapsulation process using supercritical fluids

Details Microencapsulation process using supercritical fluids Microencapsulation process using supercritical fluids

1996-10-08

1998-06-16

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 42840222, 42840224, 264 4, 427 214, 427212, 523347, 106 23C, 512 4, A61K 958, B01J 300, B01J 1304

Patent

active

057666377

ABSTRACT:
The present invention comprises a method for microencapsulating a core material comprising the steps of a) mixing a core material with an encapsulating polymer, b) supplying a supercritical fluid capable of swelling the polymer to the mixture under a temperature and a pressure sufficient to maintain the fluid in a supercritical state, c) allowing the supercritical fluid to penetrate and liquefy the polymer while maintaining temperature and pressure sufficient to maintain the fluid in a supercritical state, and d) rapidly releasing the pressure to solidify the polymer around the core material to form a microcapsule. This method requires neither that the polymer nor core materials to be soluble in the supercritical fluid and can be used to rapidly and efficiently microencapsulate a variety of materials for a variety of applications.

REFERENCES:
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Debenedetti et al., "Application of supercritical fluids for the production of sustained delivery devices", J. Controlled Release, 24:27-44 (1993).
Shine, "Polymers and Supercritical Fluids", Physical Properties of Polymers Handbook, Chapter 18, pp. 249-256, (James E. Mark ed. 1993).
Berens et al., "Application of Compressed Carbon Dioxide in the Incorporation of Additives into Polymers", J. Applied Polymer Sci., vol. 16, pp. 231-242 (1992).
Eckert et al., "Supercritical fluids as solvents for chemical and materials processing", Nature, vol. 383, pp. 313-318, Sep. 26, 1996.

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