Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...
Patent
1983-09-15
1985-05-21
Lovering, Richard D.
Plastic and nonmetallic article shaping or treating: processes
Encapsulating normally liquid material
Liquid encapsulation utilizing an emulsion or dispersion to...
8526, 2524081, 424 22, 424 32, 42840221, 514282, A61K 950, A61K 958, B01J 1302
Patent
active
045185476
ABSTRACT:
Nylon coated microcapsules containing hydrophilic solvent-soluble anionic, cationic or quaternary drug salts were prepared by interfacial polycondensation techniques. In a first stage, the drug substance to be encapsulated is dissolved in an aqueous phase. Examples of drugs encapsulated are morphine sulfate, diphenhydramine hydrochloride, and methantheline bromide. Next the aqueous drug solution is dispersed in an organic phase. In a second stage complementary polycondensation reactants each in an organic phase are added separately, either sequentially or simultaneously, to the dispersion prepared in the first stage. Microcapsules of nylon form around the hydrophilic solvent soluble core drug substance.
REFERENCES:
patent: 3575882 (1971-04-01), Vandegaer
patent: 3886084 (1975-05-01), Vassiliades
patent: 4219604 (1980-08-01), Kakimi et al.
patent: 4251386 (1981-02-01), Saeki et al.
patent: 4309213 (1982-01-01), Graber et al.
patent: 4322311 (1982-03-01), Lim et al.
patent: 4324683 (1983-04-01), Lim et al.
"Influences of Matrixes on Nylon-Encapsulated Pharmaceuticals", James W. McGinity, et al., Journal of Pharmaceutical Sciences, vol. 70(4), pp. 372-375 (1981).
"Semipermeable Aqueous Microcapsules", T. M. S. Chang, Canadian Journal of Physiology and Pharmacology, vol. 44, pp. 115-128 (1966).
George William Cuff, Dissertation: Physical-Chemical Characterization of Nylon Microencapsulated Pharmaceuticals.
Cuff George W.
McGinity James W.
Board of Regents , The University of Texas System
Lovering Richard D.
LandOfFree
Microencapsulation process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microencapsulation process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microencapsulation process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1537427