Microencapsulation of living tissue and cells

Details Microencapsulation of living tissue and cells Microencapsulation of living tissue and cells

1984-12-04

1987-08-25

Rosen, Sam

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

424110, 424424, 435178, 43524022, 604891, 604892, 604896, A01N 102

Patent

active

046892931

ABSTRACT:
Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-permeable hydrogel membrane which permits the passage of materials and oxygen to the cells and metabolic products from the cells while retaining the cells encapsulated. The biocompatible semi-permeable membrane has an outer negatively-charged surface, which imparts to the microcapsules the ability to maintain long term effectiveness.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4353888 (1982-10-01), Sefton
O'Shea et al.-Biochem at Biophysic Acta vol. 804 (1984) pp. 133-136.
Lim et al.-Science vol. 210 (Nov. 1980) pp. 980-910.

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