Microencapsulation of living tissue and cells

Details Microencapsulation of living tissue and cells Microencapsulation of living tissue and cells

1987-06-08

1989-02-21

Rosen, Sam

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424423, 43524022, 514964, A61K 944

Patent

active

048063550

ABSTRACT:
Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-permeable hydrogel membrane which permits the passage of materials and oxygen to the cells and metabolic products from the cells while retaining the cells encapsulated. The biocompatible semi-permeable membrane has an outer negatively-charged surface, which imparts to the microcapsules the ability to maintain long term effectiveness.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4353888 (1982-10-01), Sefton
O'Shea et al., Biochem et Biophysic Acta, vol. 804 (1984), pp. 133-136.
Lim et al., Science, vol. 210 (Nov. 1980), pp. 980-910.

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