Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1984-05-24
1987-06-16
Rosen, Sam
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 93, 424110, 435 1, 435178, 435180, 435240, 604890, 604891, A61K 950, A61K 3700
Patent
active
046735666
ABSTRACT:
Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-permeable hydrogel membrane based on polylysine which permits the passage of materials and oxygen to the cells and metabolic products from the cells while retaining the cells encapsulated. The biocompatible semi-permeable membrane has an outer negatively-charged surface, which, combined with a controlled thickness of polylysine of molecular weight from 10,000 to 30,000 daltons, imparts to the microcapsules the ability to maintain long term effectiveness.
REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4407957 (1983-10-01), Lim
patent: 4409331 (1983-10-01), Lim
Biocompatibility and Immunological Studies of Microencapsulation with Cross Linked Alginate Capsules, pp. 563-564, May 1982; Transplantation vol. 33, No. 5.
Microencapsulated Islets as Bioartiricial Endocrin Pancreas, by F. Lim & A. Sun Science, 11/21/80, vol. 210, pp. 908-910.
Encapsulation of Viable Tissue, F. Lim, patent application, filed Oct. 23, 1978, now abandoned (U.S. Ser. No. 953,413).
Nagaoka et al., Abstract No. 67044943, Cell Growth on Hydrogel Membranes with Relation to Surface Properties and Permeability of the Membranes.
Levine et al., Abstract No. 18030624, Parameters Affecting Cell Growth on Reduced Charge Microcarriers.
Levine et al., Abstract No. 68044855, Optimization of Growth Surface Parameters in Microcarrier Cell Culture.
Sugimoto et al., Cell Locomotion on Differently Charged Substrates Effects of Substrate Char on Locomotive Speed of Fibroblastic Cells, Abstract No. 68033245.
Boehm et al., Abstract No. 63011978, Reversible Hyperplasia and Hypertrohpy of the Mouse Liver Induced by a Functional Charge with Pheno Barbital.
M. Kierstan et al., The Immobilization of Microbial Cells, Subcellular Organelles, and Enzymes in Calcium Alginate Gels, Biotechnology and Bioengineering, vol. XIX, pp. 387-397 (1977).
U. Hackel, et al., Immobilisation of Microbial Cells in Polymeric Matrices, European J. Appl. Microbiol. 1,291-293 (1975).
K. Mosbach et al., Entrapment of Enzymes and Microorganisms in Synthetic Cross-Linked Polymers and Their Application in Column Techniques, Acta Chemica Scandinavica 20 (1966) 2807-2810.
Goosen Mattheus F. A.
O'Shea Geraldine M.
Sun Anthony M.
Connaught Laboratories Limited
Rosen Sam
LandOfFree
Microencapsulation of living tissue and cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microencapsulation of living tissue and cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microencapsulation of living tissue and cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-683099