Microencapsulation for controlled oral drug delivery system

Details Microencapsulation for controlled oral drug delivery system Microencapsulation for controlled oral drug delivery system

1991-10-10

1994-11-08

Stoll, Robert L.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 424455, 424491, 424493, 424494, 424497, A61K 952, A61K 951, A61K 950, B01J 1302

Patent

active

053624246

ABSTRACT:
A process for the microencapsulation of oil droplets containing a medical drug for oral administration, comprises the steps of mixing the drug with liquid oil by sonication for 5-30 seconds to disperse the drug homogeneously in the oil, and adding the drug-dispersed oil to an aqueous solution mixture to form a two phase system. The aqueous solution mixture will form a capsule material, and comprises a polysaccharide which has metal chelating capacity, a biocompatible and water-soluble polymer for improving the physical properties of the capsule material, and emulsifying agents. The two phase system is then subjected to sonication to produce an oil-in-water emulsion containing the drug-dispersed oil in the form of droplets having a diameter in the range of 1-5 .mu.m. As soon as possible after formation of the emulsion, the emulsion is added to a multivalent cation-containing solution to harden the capsule material. The microencapsulated emulsion is then freeze-dried to obtain a final product in a powdery state.

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