Microencapsulation by phase separation of water-soluble medicame

Details Microencapsulation by phase separation of water-soluble medicame Microencapsulation by phase separation of water-soluble medicame

1985-10-15

1987-06-16

Lovering, Richard D.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

264 43, 424450, 424497, 42840224, A61K 936, A61K 952, B01J 1302

Patent

active

046735950

ABSTRACT:
The microencapsulation of medicamentous water-soluble substances is carried out by phase separation. The operations of the hardening step take place at a temperature comprised between about 0.degree. and about 25.degree. C., the non-solvent used during this step being an aliphatic fluorinated or fluorohalogenated hydrocarbon or a mixture of such hydrocarbons. Further, the non-solvent is used in an excess with respect to the volume of solvent and non-solvent resulting from the phase-separation step.

REFERENCES:
patent: 3173878 (1965-03-01), Reyes
patent: 4166800 (1979-09-01), Fong

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