Microdialysis probes and methods of use

Details Microdialysis probes and methods of use Microdialysis probes and methods of use

1994-05-27

1995-08-15

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

128632, 128768, A61M 100, A61B 500

Patent

active

054414814

ABSTRACT:
A microdialysis probe arranged to have a primary probe, e.g., an electrical probe, secured to it so that the microdialysis probe extends about and is concentric with the primary probe to enable the combined microdialysis probe and the primary probe to be extended as a unit through a common opening into the body of a living being, whereupon the microdialysis probe can be used for selective sampling and/or administration of dialyzable compounds in biological fluids from living tissue within the body of the being and the primary probe can be used for some other function within the body of the being without appreciably injuring adjacent tissue. The microdialysis probe comprises a tube having a lumen therethrough for releasably mounting the primary probe, and at least one dialysis chamber. In one embodiment only a single annular dialysis chamber is provided with the lumen mounting the primary probe extending therethrough. In another embodiment two semi-annular dialysis chambers are provided adjacent each other with the lumen mounting the primary probe extending therethrough. In either case each dialysis chamber comprises a wall formed of a semi-permeable material, an inlet passageway to the chamber and an outlet passageway from the chamber.

REFERENCES:
patent: 2936761 (1960-05-01), Snyder
patent: 3995623 (1976-12-01), Blake et al.
patent: 4072146 (1978-02-01), Howes
patent: 4235231 (1980-11-01), Schindler et al.
patent: 4274417 (1981-06-01), Delpy
patent: 4406656 (1983-09-01), Hattler
patent: 4437856 (1984-03-01), Valli
patent: 4516580 (1985-05-01), Polyani
patent: 4623329 (1986-11-01), Drobish et al.
patent: 4645494 (1987-02-01), Lee et al.
patent: 4694832 (1987-09-01), Ungerstedt
patent: 4850373 (1989-06-01), Zatloukal et al.
patent: 4894057 (1990-01-01), Howes
patent: 4901727 (1990-02-01), Goodwin
patent: 4903707 (1990-02-01), Knute et al.
patent: 4931049 (1990-06-01), Klimas
patent: 4994072 (1991-02-01), Bhate et al.
patent: 5024654 (1991-06-01), Tyler
patent: 5106365 (1992-04-01), Hernandez
patent: 5191898 (1993-03-01), Millar
patent: 5191900 (1993-03-01), Mishra
patent: 5207640 (1993-05-01), Hattler
patent: 5212527 (1993-06-01), Beck
patent: 5254084 (1993-10-01), Geary
patent: 5342385 (1994-08-01), Norelli et al.
Obrenovitch, et al., "Combined Intracerebral Microdialysis and Electrophysiological Recording: Methodology and Applications," Journal of Neuroscience Methods, vol. 47 (1993), pp. 139-145.
Yadid, et al., "Modified Microdialalysis Probe for Sampling Extracellular Fluid and Administering Drugs In Vivo," American Journal of Physiology, vol. 265 (1993), pp. R1205-R1211.

Affiliated with

Also associated with

Rating

Microdialysis probes and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microdialysis probes and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microdialysis probes and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2178254