Microcrystals comprising an active substance having an affinity

Details Microcrystals comprising an active substance having an affinity Microcrystals comprising an active substance having an affinity

1989-06-08

1990-11-27

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424417, 424498, 424499, 424502, 514 31, A01N 2532

Patent

active

049734652

ABSTRACT:
The present invention relates to microcrystals of a substance, which substance is insoluble in water and has an affinity for phospholipids, as well as a process for its preparation. According to the invention, one or more organic solvents are evaporated from a solution of phospholipids and substance, and the film obtained thereby, after evaporation of the one or more solvents, is suspended in an aqueous solution by vigorous stirring. The invention also relates to pharmaceutical compositions containing as active principle these microcrystals, particularly liquid pharmaceutical compositions packaged in injectable form or in sprayable form.

REFERENCES:
patent: Re32393 (1987-04-01), Wretlind et al.
patent: 2664380 (1953-12-01), Vierling
patent: 4396630 (1983-08-01), Riedl et al.
patent: 4647586 (1987-03-01), Mizushima et al.
patent: 4687762 (1987-08-01), Fukushima et al.
patent: 4727077 (1988-02-01), Hega et al.
"Characteristics of Drug-Phospholipid Coprecipitates I: Physical Properties and Dissolution Behavior of Griseofulvin-Dimyristoylophosphatidylcholine Systems", Journal of Pharmaceutical Sciences, vol. 73, #6, 6/84, pp. 757-761, S. Venkataram et al., Amer. Pharmaceutical Assoc., Wash.

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