Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1984-09-20
1987-06-02
Foelak, Morton
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
524 56, 426583, 427 3, A61K 700, A61K 716, A23C 2100, A23C 2102
Patent
active
046702512
ABSTRACT:
A solid pharmaceutical composition suitable for oral or rectal administration comprising a unit dosage of a pharmaceutically active ingredient (and optionally one or more inert fillers) homogeneously dispersed in a pharmaceutically acceptable binder, wherein at least a major portion (i.e., at least 50% by weight) of the binder is a microcrystalline solid phase prepared by raising the pH of a dairy whey lactose permeate having a pH below about 7 to a pH between about 8 and 10 to form (i) a lactose-rich aqueous solute phase capable of being autoclaved for 10-20 minutes at 121.degree. C. and 15 psi to form a clear, light-colored solute having a pH of about 7; and (ii) a microcrystalline solid phase which contains substantially all of the dissolved solids from said solute phase which would form a precipitate upon autoclaving said solid phase; separating the microcrystalline solid phase from the solute phase; and drying the separated microcrystalline solid phase to form a nontoxic, tasteless, odorless, chalky white free-flowing powder.
REFERENCES:
patent: 3922339 (1975-11-01), Shear
patent: 4036999 (1977-07-01), Grindstaff
Pernarowski, M., PhD, "Solutions, Emulsions and Suspensions", Chapter 83, Remington's Pharmaceutical Sciences (15th Edition, 1975, pp. 1436-1460).
Baichwal, A. R. and Shangraw, Ralph F., "Tableting Properties of a New Protein/Lactose/Mineral Complex", Pharmaceutical Technology, (Sep. 1985).
Foelak Morton
Haight James C.
Igene Biotechnology Inc.
Nutter Nathan M.
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