Microcrystalline cellulose spheronization composition

Details Microcrystalline cellulose spheronization composition Microcrystalline cellulose spheronization composition

1994-09-26

1998-03-10

Weberman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424500, A61K 916

Patent

active

057258864

ABSTRACT:
A particulate co-processed unattrited microcrystalline cellulose:hydrocolloid composition wherein the respective components are present in a weight ratio of from about 99:1 to 70:30. The composition is useful as a spheronizing agent for producing spheroids of uniform size and sphericity and having high drug loadings. The composition is produced by drying a slurry of the microcrystalline cellulose in an aqueous solution of the hydrocolloid. The preferred hydrocolloid is methylcellulose.

REFERENCES:
patent: 4421778 (1983-12-01), Kahn et al.
patent: 4837030 (1989-06-01), Valorose, Jr. et al.
patent: 4867985 (1989-09-01), Heafield et al.

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