Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-05-07
2009-06-02
Berch, Mark L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S267000
Reexamination Certificate
active
07541363
ABSTRACT:
Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.
REFERENCES:
patent: 5543415 (1996-08-01), Suzuki et al.
patent: 5587378 (1996-12-01), Suzuki et al.
patent: 6254889 (2001-07-01), Kigoshi et al.
patent: 2006/0029663 (2006-02-01), Uchida et al.
patent: 09040652 (1997-02-01), None
Abstract for JP 9040652 (Feb. 1997).
Aoki Noboru
Asanome Kazuki
Hayakawa Eiji
Ishikawa Yasuhiro
Kigoshi Makoto
Berch Mark L
Fitzpatrick ,Cella, Harper & Scinto
Kyowa Hakko Kirin Co., Ltd.
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