Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer
Patent
1995-07-24
1997-07-08
Drodge, Joseph W.
Chemistry: analytical and immunological testing
Including sample preparation
Volumetric liquid transfer
96106, 204601, 2101982, 285911, 422 70, 422103, G01N 110, G01N 3002, B01D 1508
Patent
active
056460481
ABSTRACT:
A microcolumnar analytical apparatus having a flow gating interface system for interfacing a first microcolumn and a second microcolumn is provided. The apparatus includes a flow gating interface, a first fluid conduit (e.g. a liquid chromatograph microcolumn) of a fluid sample, a flush liquid supplier, and a second fluid conduit (e.g. a capillary electrophoresis microcolumn) for analysis of the effluent fluid sample from the first fluid conduit. The flow gating interface includes a first microcolumnar section, a second microcolumnar section, and a channel. The channel, having an inwardly facing wall, encloses at least a portion each of the first microcolumnar section and the second microcolumnar section for conducting a flush fluid flow past the outlet end of the first microcolumnar section and the inlet end of the second microcolumnar section. The inwardly facing wall of the channel nonfixedly constrains and aligns said end portions of the first and second microcolumnar section due to the relative curvature and elasticity of the microcolumnar sections and the channel. The first fluid conduct is connected to and in fluid communication with the first microcolumnar section of the flow gating interface. The second fluid conducting means has a microcolumn. This microcolumn is connected to and in fluid communication with the second microcolumnar section of the flow gating interface. The flush liquid supplier is connected to and in fluid communication with the channel.
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McManigill Douglass
Templin Catherine Keely
Drodge Joseph W.
Hewlett--Packard Company
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