Microcapsules of predetermined peptide(s) specificity (ies), the

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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Details

424491, 424492, 424493, 424494, 424497, A61K 916, A61K 950

Patent

active

056861133

ABSTRACT:
An aqueous core microcapsule has a capsular wall provided with a peptide(s) of pre-determined binding specificity(ies) appended to the surface, the wall being the reaction product of an anionic polymer or salt thereof and a polyamine, salt thereof, mixtures thereof, or mixtures thereof with monoamines. The aqueous core may contain an active ingredient(s), and be targeted for delivery to specific cell tissues. The microcapsules are provided as a composition and in a kit with instructions for use in imaging, diagnosis, therapy, vaccination, and other applications.

REFERENCES:
patent: 3137631 (1964-06-01), Soloway
patent: 3959457 (1976-05-01), Speaker et al.
patent: 4205060 (1980-05-01), Monsimer et al.
patent: 4606940 (1986-08-01), Frank et al.
patent: 4744933 (1988-05-01), Rha et al.
patent: 5132117 (1992-07-01), Speaker et al.
J.D. Andrade et al., "Coated adsorbents for direct blood perfusion: HAMA/activated carbon", Trans. Amer. Soc. Artif. Int. Organs. 17:222-228 (1971).
F. Lim & Sun, "Microencapsulated Islets as Bioartificial Endocrine Pancreas", Science 210:908-910 (1980).
Gref et al., "Biodegradable Long-Circulating Polymeric Nanospheres", Science 263:1600-1603 (1994).
Torchilin et al., "Targeted accumulation of polyethylene glycol-coated Immunoliposomes in Infected rabbit myocardium", J. Fed. Amer. Soc. Expl. Biol. 6:2716-2719 (1992).
Illum et al., Biomaterials 8:113 (1987).
Lee et al., "Protein Adsorption on Pluronic Copolymer Coated Polystyrene Particles", J. Colloid Interface Sci. 131:252-266 (1989).
Lehr, C.M. et al., "Bioadhesion by Means of Specific Binding of Tomato Lectin", Pharm. Res. 9:547-553 (1992).
Urdal and Hakomori "Tumor-associated Ganglio-N-triosylceramide", J. Biol. Chem. 255:10509-10515 (1980).
Weinstein et al., "Antibody Medicated Targeting of Liposomes Binding to Lymphocytes Does Not Insure Incorporation of Vesicle Contents into Cells", B. B. A. 509:272-288 (1978).
Leserman et al., "Binding of Antigen-Bearing Fluorescent Liposomes to the Murine Myeloma Tumor MOPC 315", J. Immunol. 122:585-591 (1979).
Rivnay and Wilchek, "Use of Avidin-Biotin Technology for Liposome Targeting", in Methods in Enzymology 149:119-123 (1987).

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