Microcapsules having mixed walls formed of reticulated polyholos

Details Microcapsules having mixed walls formed of reticulated polyholos Microcapsules having mixed walls formed of reticulated polyholos

1986-08-07

1988-10-25

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

264 432, 4284022, B32B 516

Patent

active

047803215

ABSTRACT:
A process for preparing microcapsules containing a pharmaceutically active substance of a water soluble nature is provided, which involves dissolving a mixture containing at least one water soluble polyholoside or water soluble derivative of a polyholoside, at least one protein, and the pharmaceutically active substance in an alkaline aqueous solution having a pH preferably above 10, the solution being emulsified by dispersion within an immiscible organic solvent, by addition of an emulsifier of the water in oil type and by stirring. Thereafter, a reticulation agent dissolved in the same immiscible organic solvent is added to the previously obtained emulsion being stirred, and the stirring is continued until interfacial reticulation is achieved. The microcapsules are then isolated by diluting the reaction mixture with solvent, or a mixture of solvents and then centrifugation or decantation.

REFERENCES:
patent: 3578605 (1971-05-01), Baxter
patent: 4138362 (1979-02-01), Vassiliades et al.
M. C. Levy et al.-2nd Congress Int. Technol. Pharm. Paris-1980, III, pp. 15-24.

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